Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia
Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2020
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| Online Access: | https://hdl.handle.net/1721.1/126017 |
| _version_ | 1826201355083055104 |
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| author | Laiton-Donato, Katherine Alvarez, Diego A Peláez-Carvajal, Dioselina Mercado, Marcela Ajami, Nadim J Bosch, Irene Usme-Ciro, José A |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Laiton-Donato, Katherine Alvarez, Diego A Peláez-Carvajal, Dioselina Mercado, Marcela Ajami, Nadim J Bosch, Irene Usme-Ciro, José A |
| author_sort | Laiton-Donato, Katherine |
| collection | MIT |
| description | Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013–2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. |
| first_indexed | 2024-09-23T11:50:19Z |
| format | Article |
| id | mit-1721.1/126017 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:50:19Z |
| publishDate | 2020 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | mit-1721.1/1260172022-09-27T22:17:06Z Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia Laiton-Donato, Katherine Alvarez, Diego A Peláez-Carvajal, Dioselina Mercado, Marcela Ajami, Nadim J Bosch, Irene Usme-Ciro, José A Massachusetts Institute of Technology. Institute for Medical Engineering & Science Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013–2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification. 2020-06-29T18:54:31Z 2020-06-29T18:54:31Z 2019-05 2019-03 2020-06-26T11:05:36Z Article http://purl.org/eprint/type/JournalArticle 1743-422X https://hdl.handle.net/1721.1/126017 Laiton-Donato, Katherine et al. "Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia." Virology Journal 16, 1 (May 2019): 62 © 2019 Springer Nature en https://doi.org/10.1186/s12985-019-1170-4 Virology Journal Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ The Author(s). application/pdf BioMed Central BioMed Central |
| spellingShingle | Laiton-Donato, Katherine Alvarez, Diego A Peláez-Carvajal, Dioselina Mercado, Marcela Ajami, Nadim J Bosch, Irene Usme-Ciro, José A Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title | Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title_full | Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title_fullStr | Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title_full_unstemmed | Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title_short | Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia |
| title_sort | molecular characterization of dengue virus reveals regional diversification of serotype 2 in colombia |
| url | https://hdl.handle.net/1721.1/126017 |
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