A dual palladium and copper hydride catalyzed approach for alkyl-aryl cross-coupling of aryl halides and olefins

We report an efficient means of sp2-sp3 cross coupling for a variety of terminal monosubstituted olefins with aryl electrophiles using Pd and CuH catalysis. In addition to its applicability to a range of aryl bromide substrates, this process was also suitable for electron-deficient aryl chlorides, f...

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Bibliographic Details
Main Authors: Friis, Stig During, Pirnot, Michael T, Dupuis, Lauren N., Buchwald, Stephen Leffler
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/126026

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