Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes

Activation of the Wnt signaling pathway promotes lung cancer progression and contributes to poor patient prognosis. The porcupine inhibitor LGK974, a novel orally bioavailable cancer therapeutic in Phase I clinical trials, induces potent Wnt signaling inhibition and leads to suppressed growth and pr...

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Bibliographic Details
Main Authors: Guimaraes, Pedro P G, Tan, Mingchee, Tammela, Tuomas, Wu, Katherine, Chung, Amanda T, Oberli, Matthias, Wang, Karin, Spektor, Roman, Riley, Rachel S., Viana, Celso T.R., Jacks, Tyler E, Langer, Robert S, Mitchell, Michael J.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126038

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