Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1

Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1

Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug target for epilepsy and neuropathic pain; thus the TSP-α2δ-1 interaction is implicated in both synaptic development and dis...

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Bibliographic Details
Main Authors: Risher, W. Christopher, Kim, Namsoo, Koh, Sehwon, Choi, Ji-Eun, Mitev, Petar, Spence, Erin F., Pilaz, Louis-Jan, Wang, Dongqing, Feng, Guoping, Silver, Debra L., Soderling, Scott H., Yin, Henry H., Eroglu, Cagla
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: Rockefeller University Press 2020
Online Access:https://hdl.handle.net/1721.1/126047

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