Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

Pancreatic ductal adenocarcinoma (PDAC) has prominent extracellular matrix (ECM) that compromises treatments yet cannot be nonselectively disrupted without adverse consequences. ECM of PDAC, despite the recognition of its importance, has not been comprehensively studied in patients. In this study, w...

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Bibliographic Details
Main Authors: Tian, Chenxi, Clauser, Karl R., Öhlund, Daniel, Rickelt, Steffen, Huang, Ying, Gupta, Mala, Mani, D. R., Carr, Steven A., Tuveson, David A., Hynes, Richard O
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences 2020
Online Access:https://hdl.handle.net/1721.1/126050

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