Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival
Cancer develops by accumulation of somatic driver mutations, which impact cellular function. Mutations in non-coding regulatory regions can now be studied genome-wide and further characterized by correlation with gene expression and clinical outcome to identify driver candidates. Using a new two-sta...
Main Authors: | Hornshøj, Henrik, Nielsen, Morten Muhlig, Sinnott-Armstrong, Nicholas A., Świtnicki, Michał P., Juul, Malene, Madsen, Tobias, Sallari, Richard, Kellis, Manolis, Ørntoft, Torben, Hobolth, Asger, Pedersen, Jakob Skou |
---|---|
Other Authors: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2020
|
Online Access: | https://hdl.handle.net/1721.1/126059 |
Similar Items
-
Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
by: Malene Juul, et al.
Published: (2017-03-01) -
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data
by: Johanna Bertl, et al.
Published: (2018-04-01) -
ncdDetect2: Improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation
by: Juul, Malene, et al.
Published: (2021) -
ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation
by: Juul, Malene, et al.
Published: (2022) -
miRNA activity inferred from single cell mRNA expression
by: Morten Muhlig Nielsen, et al.
Published: (2021-04-01)