Enhanced Dendritic Compartmentalization in Human Cortical Neurons
The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear how their size affects synaptic integration. Here, we perform direct electrical recordings from human dendrites and report enhanced electrical...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126118 |
| _version_ | 1826217544503001088 |
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| author | Beaulieu-Laroche, Lou Toloza, Enrique Van der Goes, Marie-Sophie Lafourcade, Mathieu Barnagian, Derrick G. Williams, Ziv M. Eskandar, Emad N. Frosch, Matthew P. Cash, Sydney S. Harnett, Mark T. |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Beaulieu-Laroche, Lou Toloza, Enrique Van der Goes, Marie-Sophie Lafourcade, Mathieu Barnagian, Derrick G. Williams, Ziv M. Eskandar, Emad N. Frosch, Matthew P. Cash, Sydney S. Harnett, Mark T. |
| author_sort | Beaulieu-Laroche, Lou |
| collection | MIT |
| description | The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear how their size affects synaptic integration. Here, we perform direct electrical recordings from human dendrites and report enhanced electrical compartmentalization in layer 5 pyramidal neurons. Compared to rat dendrites, distal human dendrites provide limited excitation to the soma, even in the presence of dendritic spikes. Human somas also exhibit less bursting due to reduced recruitment of dendritic electrogenesis. Finally, we find that decreased ion channel densities result in higher input resistance and underlie the lower coupling of human dendrites. We conclude that the increased length of human neurons alters their input-output properties, which will impact cortical computation. Video Abstract: Human cortical neurons exhibit a higher degree of voltage compartmentalization compared to rodent counterparts due to lower ion channel densities across larger dendritic surfaces. |
| first_indexed | 2024-09-23T17:05:01Z |
| format | Article |
| id | mit-1721.1/126118 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:05:01Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1261182022-10-03T10:18:38Z Enhanced Dendritic Compartmentalization in Human Cortical Neurons Beaulieu-Laroche, Lou Toloza, Enrique Van der Goes, Marie-Sophie Lafourcade, Mathieu Barnagian, Derrick G. Williams, Ziv M. Eskandar, Emad N. Frosch, Matthew P. Cash, Sydney S. Harnett, Mark T. McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences The biophysical features of neurons shape information processing in the brain. Cortical neurons are larger in humans than in other species, but it is unclear how their size affects synaptic integration. Here, we perform direct electrical recordings from human dendrites and report enhanced electrical compartmentalization in layer 5 pyramidal neurons. Compared to rat dendrites, distal human dendrites provide limited excitation to the soma, even in the presence of dendritic spikes. Human somas also exhibit less bursting due to reduced recruitment of dendritic electrogenesis. Finally, we find that decreased ion channel densities result in higher input resistance and underlie the lower coupling of human dendrites. We conclude that the increased length of human neurons alters their input-output properties, which will impact cortical computation. Video Abstract: Human cortical neurons exhibit a higher degree of voltage compartmentalization compared to rodent counterparts due to lower ion channel densities across larger dendritic surfaces. National Institutes of Health (Grant RO1NS106031) 2020-07-09T20:05:16Z 2020-07-09T20:05:16Z 2018-10 2018-06 2019-12-10T13:03:45Z Article http://purl.org/eprint/type/JournalArticle 0092-8674 https://hdl.handle.net/1721.1/126118 Beaulieu-Laroche, Lou et al. "Enhanced Dendritic Compartmentalization in Human Cortical Neurons." Cell 175, 3 (October 2018): P643-651.e14 en http://dx.doi.org/10.1016/j.cell.2018.08.045 Cell Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Beaulieu-Laroche, Lou Toloza, Enrique Van der Goes, Marie-Sophie Lafourcade, Mathieu Barnagian, Derrick G. Williams, Ziv M. Eskandar, Emad N. Frosch, Matthew P. Cash, Sydney S. Harnett, Mark T. Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title | Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title_full | Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title_fullStr | Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title_full_unstemmed | Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title_short | Enhanced Dendritic Compartmentalization in Human Cortical Neurons |
| title_sort | enhanced dendritic compartmentalization in human cortical neurons |
| url | https://hdl.handle.net/1721.1/126118 |
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