DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

Alcoholic liver disease (ALD) is characterized by lipid accumulation and liver injury. However, how chronic alcohol consumption causes hepatic lipid accumulation remains elusive. The present study demonstrates that activation of the mechanistic target of rapamycin complex 1 (mTORC1) plays a causal r...

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Bibliographic Details
Main Authors: Chen, Hanqing, Shen, Feng, Sherban, Alex, Nocon, Allison, Li, Yu, Wang, Hua, Xu, Ming-Jiang, Rui, Xianliang, Han, Jinyan, Jiang, Bingbing, Lee, Donghwan, Li, Na, Keyhani-Nejad, Farnaz, Fan, Jian-gao, Liu, Feng, Kamat, Amrita, Musi, Nicolas, Guarente, Leonard Pershing, Pacher, Pal, Gao, Bin, Zang, Mengwei
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Wiley 2020
Online Access:https://hdl.handle.net/1721.1/126133

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