Reward magnitude tracking by neural populations in ventral striatum
Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126205 |
| _version_ | 1826197657123553280 |
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| author | Fiallos, Ana Bricault, Sarah Jean Cai, Lili X. Worku, Hermoon A. Colonnese, Matthew T Westmeyer, Gil Gregor Jasanoff, Alan Pradip |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Fiallos, Ana Bricault, Sarah Jean Cai, Lili X. Worku, Hermoon A. Colonnese, Matthew T Westmeyer, Gil Gregor Jasanoff, Alan Pradip |
| author_sort | Fiallos, Ana |
| collection | MIT |
| description | Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad network of structures activated by behaviorally characterized levels of rewarding stimulation. Correlation of psychometric behavioral measurements with fMRI response magnitudes revealed regions whose activity corresponded closely to the subjective magnitude of rewards. The largest and most reliable focus of reward magnitude tracking was observed in the shell region of the nucleus accumbens (NAc). Although the nonlinear nature of neurovascular coupling complicates interpretation of fMRI findings in precise neurophysiological terms, reward magnitude tracking was not observed in vascular compartments and could not be explained by saturation of region-specific hemodynamic responses. In addition, local pharmacological inactivation of NAc changed the profile of animals’ responses to rewards of different magnitudes without altering mean reward response rates, further supporting a hypothesis that neural population activity in this region contributes to assessment of reward magnitudes. |
| first_indexed | 2024-09-23T10:51:08Z |
| format | Article |
| id | mit-1721.1/126205 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:51:08Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1262052022-09-30T23:30:03Z Reward magnitude tracking by neural populations in ventral striatum Fiallos, Ana Bricault, Sarah Jean Cai, Lili X. Worku, Hermoon A. Colonnese, Matthew T Westmeyer, Gil Gregor Jasanoff, Alan Pradip Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Nuclear Science and Engineering McGovern Institute for Brain Research at MIT Evaluation of the magnitudes of intrinsically rewarding stimuli is essential for assigning value and guiding behavior. By combining parametric manipulation of a primary reward, medial forebrain bundle (MFB) microstimulation, with functional magnetic imaging (fMRI) in rodents, we delineated a broad network of structures activated by behaviorally characterized levels of rewarding stimulation. Correlation of psychometric behavioral measurements with fMRI response magnitudes revealed regions whose activity corresponded closely to the subjective magnitude of rewards. The largest and most reliable focus of reward magnitude tracking was observed in the shell region of the nucleus accumbens (NAc). Although the nonlinear nature of neurovascular coupling complicates interpretation of fMRI findings in precise neurophysiological terms, reward magnitude tracking was not observed in vascular compartments and could not be explained by saturation of region-specific hemodynamic responses. In addition, local pharmacological inactivation of NAc changed the profile of animals’ responses to rewards of different magnitudes without altering mean reward response rates, further supporting a hypothesis that neural population activity in this region contributes to assessment of reward magnitudes. United States. Defense Advanced Research Projects Agency (Grant W911NF-10-0059) National Institutes of Health (U.S.) (Grant R01-DA028299) National Institutes of Health (U.S.) (Grant R01-DA038642) 2020-07-15T16:41:37Z 2020-07-15T16:41:37Z 2017-02 2020-03-11T16:32:36Z Article http://purl.org/eprint/type/JournalArticle 1053-8119 https://hdl.handle.net/1721.1/126205 Fiallos, Ana M. et al. “Reward magnitude tracking by neural populations in ventral striatum.” NeuroImage, vol. 146, 2017, pp. 1003-1015 © 2017 The Author(s) en 10.1016/J.NEUROIMAGE.2016.10.036 NeuroImage Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Fiallos, Ana Bricault, Sarah Jean Cai, Lili X. Worku, Hermoon A. Colonnese, Matthew T Westmeyer, Gil Gregor Jasanoff, Alan Pradip Reward magnitude tracking by neural populations in ventral striatum |
| title | Reward magnitude tracking by neural populations in ventral striatum |
| title_full | Reward magnitude tracking by neural populations in ventral striatum |
| title_fullStr | Reward magnitude tracking by neural populations in ventral striatum |
| title_full_unstemmed | Reward magnitude tracking by neural populations in ventral striatum |
| title_short | Reward magnitude tracking by neural populations in ventral striatum |
| title_sort | reward magnitude tracking by neural populations in ventral striatum |
| url | https://hdl.handle.net/1721.1/126205 |
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