Image-guided neural activity manipulation with a paramagnetic drug
Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/126211 |
| _version_ | 1826196103363559424 |
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| author | Bricault, Sarah Jean Barandov, Ali Harvey, Peter DeTienne, Elizabeth Hai, Aviad Jasanoff, Alan Pradip |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bricault, Sarah Jean Barandov, Ali Harvey, Peter DeTienne, Elizabeth Hai, Aviad Jasanoff, Alan Pradip |
| author_sort | Bricault, Sarah Jean |
| collection | MIT |
| description | Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity. |
| first_indexed | 2024-09-23T10:21:13Z |
| format | Article |
| id | mit-1721.1/126211 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:21:13Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1262112022-09-30T20:35:45Z Image-guided neural activity manipulation with a paramagnetic drug Bricault, Sarah Jean Barandov, Ali Harvey, Peter DeTienne, Elizabeth Hai, Aviad Jasanoff, Alan Pradip Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of the drug muscimol that enables targeted neural inactivation to be performed with feedback from magnetic resonance imaging. We validate pharmacological properties of the compound in vitro, and show that its distribution in vivo reliably predicts perturbations to brain activity. National Institutes of Health (U.S.) (Grant R01 DA038642) National Institutes of Health (U.S.) (Grant UF1 NS107712) National Institutes of Health (U.S.) (Grant U01 NS103470) National Institutes of Health (U.S.) (Grant T32 EB019940) Wellcome Trust-MIT Fellowship (105932/Z/14/Z) 2020-07-15T21:02:39Z 2020-07-15T21:02:39Z 2020-01 2020-03-11T17:24:26Z Article http://purl.org/eprint/type/JournalArticle 2041-1723 https://hdl.handle.net/1721.1/126211 Bricault, Sarah et al. “Image-guided neural activity manipulation with a paramagnetic drug.” Nature Communications, vol. 11, 2020, article 136 © 2020 The Author(s) en 10.1038/s41467-019-13933-5 Nature Communications Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Bricault, Sarah Jean Barandov, Ali Harvey, Peter DeTienne, Elizabeth Hai, Aviad Jasanoff, Alan Pradip Image-guided neural activity manipulation with a paramagnetic drug |
| title | Image-guided neural activity manipulation with a paramagnetic drug |
| title_full | Image-guided neural activity manipulation with a paramagnetic drug |
| title_fullStr | Image-guided neural activity manipulation with a paramagnetic drug |
| title_full_unstemmed | Image-guided neural activity manipulation with a paramagnetic drug |
| title_short | Image-guided neural activity manipulation with a paramagnetic drug |
| title_sort | image guided neural activity manipulation with a paramagnetic drug |
| url | https://hdl.handle.net/1721.1/126211 |
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