Formulations for trans-tympanic antibiotic delivery
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126215 |
| _version_ | 1826192914655477760 |
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| author | Khoo, Xiaojuan Simons, Emmanuel John Chiang, Homer H. Hickey, Julia M. Sabharwal, Vishakha Pelton, Stephen I. Rosowski, John J Langer, Robert Kohane, Daniel S |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Khoo, Xiaojuan Simons, Emmanuel John Chiang, Homer H. Hickey, Julia M. Sabharwal, Vishakha Pelton, Stephen I. Rosowski, John J Langer, Robert Kohane, Daniel S |
| author_sort | Khoo, Xiaojuan |
| collection | MIT |
| description | We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd. |
| first_indexed | 2024-09-23T09:31:07Z |
| format | Article |
| id | mit-1721.1/126215 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:31:07Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1262152022-09-26T11:58:29Z Formulations for trans-tympanic antibiotic delivery Khoo, Xiaojuan Simons, Emmanuel John Chiang, Homer H. Hickey, Julia M. Sabharwal, Vishakha Pelton, Stephen I. Rosowski, John J Langer, Robert Kohane, Daniel S Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Chemical Engineering We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases. ©2012 Elsevier Ltd. National Institute of Deafness andCommunicative Disorders - NIDCD (Grant Number R21DC009986) 2020-07-15T22:02:12Z 2020-07-15T22:02:12Z 2012-11 2012-09 2019-09-05T15:47:30Z Article http://purl.org/eprint/type/JournalArticle 1878-5905 https://hdl.handle.net/1721.1/126215 Khoo, Xiaojuan et al., "Formulations for trans-tympanic antibiotic delivery." Biomaterials 34, 4 (January 2013): p. 1281-88 doi. 10.1016/j.biomaterials.2012.10.025 ©2012 Authors en https://dx.doi.org/10.1016/j.biomaterials.2012.10.025 Biomaterials Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Khoo, Xiaojuan Simons, Emmanuel John Chiang, Homer H. Hickey, Julia M. Sabharwal, Vishakha Pelton, Stephen I. Rosowski, John J Langer, Robert Kohane, Daniel S Formulations for trans-tympanic antibiotic delivery |
| title | Formulations for trans-tympanic antibiotic delivery |
| title_full | Formulations for trans-tympanic antibiotic delivery |
| title_fullStr | Formulations for trans-tympanic antibiotic delivery |
| title_full_unstemmed | Formulations for trans-tympanic antibiotic delivery |
| title_short | Formulations for trans-tympanic antibiotic delivery |
| title_sort | formulations for trans tympanic antibiotic delivery |
| url | https://hdl.handle.net/1721.1/126215 |
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