Not All T Cell Synapses Are Built the Same Way
T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appreciated in gene expression studies, functional assays, and di...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Cell Press/Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126232 |
| _version_ | 1811095327984320512 |
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| author | Kumari, Sudha Colin-York, Huw Irvine, Darrell J Fritzsche, Marco |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Kumari, Sudha Colin-York, Huw Irvine, Darrell J Fritzsche, Marco |
| author_sort | Kumari, Sudha |
| collection | MIT |
| description | T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appreciated in gene expression studies, functional assays, and disease models. Yet, our understanding of the principles underlying T cell subtype-specific activation and antigen recognition in the immunological synapse remains limited. This is primarily due to difficulties in primary T cell visualization at high spatiotemporal resolution and the adoption of tractable transformed T cell systems for cell biological experiments that may not correctly represent primary T cell constitutional diversity. Here, we discuss recent findings regarding the architectural and dynamic diversity of the immunological synapse and state-of-the-art methodologies that can be utilized to provide clues on how biological and biophysical differences in synaptic make-up could govern functional divergences in T cell subtypes. |
| first_indexed | 2024-09-23T16:15:20Z |
| format | Article |
| id | mit-1721.1/126232 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:15:20Z |
| publishDate | 2020 |
| publisher | Cell Press/Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1262322024-06-25T20:32:19Z Not All T Cell Synapses Are Built the Same Way Kumari, Sudha Colin-York, Huw Irvine, Darrell J Fritzsche, Marco Koch Institute for Integrative Cancer Research at MIT Massachusetts Institute of Technology. Department of Biological Engineering T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appreciated in gene expression studies, functional assays, and disease models. Yet, our understanding of the principles underlying T cell subtype-specific activation and antigen recognition in the immunological synapse remains limited. This is primarily due to difficulties in primary T cell visualization at high spatiotemporal resolution and the adoption of tractable transformed T cell systems for cell biological experiments that may not correctly represent primary T cell constitutional diversity. Here, we discuss recent findings regarding the architectural and dynamic diversity of the immunological synapse and state-of-the-art methodologies that can be utilized to provide clues on how biological and biophysical differences in synaptic make-up could govern functional divergences in T cell subtypes. 2020-07-17T13:59:33Z 2020-07-17T13:59:33Z 2019-10 2020-03-11T14:03:10Z Article http://purl.org/eprint/type/JournalArticle 1471-4906 https://hdl.handle.net/1721.1/126232 Kumari, Sudha et al. "Not All T Cell Synapses Are Built the Same Way." Trends in Immunology 40, 11 (November 2019): P977-980 © 2019 The Author(s) en http://dx.doi.org/10.1016/j.it.2019.09.009 Trends in Immunology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Cell Press/Elsevier BV Elsevier |
| spellingShingle | Kumari, Sudha Colin-York, Huw Irvine, Darrell J Fritzsche, Marco Not All T Cell Synapses Are Built the Same Way |
| title | Not All T Cell Synapses Are Built the Same Way |
| title_full | Not All T Cell Synapses Are Built the Same Way |
| title_fullStr | Not All T Cell Synapses Are Built the Same Way |
| title_full_unstemmed | Not All T Cell Synapses Are Built the Same Way |
| title_short | Not All T Cell Synapses Are Built the Same Way |
| title_sort | not all t cell synapses are built the same way |
| url | https://hdl.handle.net/1721.1/126232 |
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