Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell...
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| Iaith: | English |
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Elsevier BV
2020
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| Mynediad Ar-lein: | https://hdl.handle.net/1721.1/126263 |
| _version_ | 1826217244321906688 |
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| author | Pignatelli di Spinazzola, Michele Rivera, Tomás Roy, Dheeraj Lovett, Chanel W. L. Smith, Lillian Muralidhar, Shruti Tonegawa, Susumu |
| author2 | RIKEN-MIT Center for Neural Circuit Genetics |
| author_facet | RIKEN-MIT Center for Neural Circuit Genetics Pignatelli di Spinazzola, Michele Rivera, Tomás Roy, Dheeraj Lovett, Chanel W. L. Smith, Lillian Muralidhar, Shruti Tonegawa, Susumu |
| author_sort | Pignatelli di Spinazzola, Michele |
| collection | MIT |
| description | Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell excitability is transiently increased following memory reactivation. This short-term increase of engram excitability enhances the subsequent retrieval of specific memory content in response to cues and is manifest in the animal's ability to recognize contexts more precisely and more effectively. These results reveal a hitherto unknown transient enhancement of context recognition based on the plasticity of engram cell excitability. They also suggest that recall of a contextual memory is influenced by previous but recent activation of the same engram. The state of excitability of engram cells mediates differential behavioral outcomes upon memory retrieval and may be crucial for survival by promoting adaptive behavior. |
| first_indexed | 2024-09-23T17:00:17Z |
| format | Article |
| id | mit-1721.1/126263 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:00:17Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1262632022-10-03T09:46:22Z Engram Cell Excitability State Determines the Efficacy of Memory Retrieval Pignatelli di Spinazzola, Michele Rivera, Tomás Roy, Dheeraj Lovett, Chanel W. L. Smith, Lillian Muralidhar, Shruti Tonegawa, Susumu RIKEN-MIT Center for Neural Circuit Genetics Massachusetts Institute of Technology. Department of Biology Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell excitability is transiently increased following memory reactivation. This short-term increase of engram excitability enhances the subsequent retrieval of specific memory content in response to cues and is manifest in the animal's ability to recognize contexts more precisely and more effectively. These results reveal a hitherto unknown transient enhancement of context recognition based on the plasticity of engram cell excitability. They also suggest that recall of a contextual memory is influenced by previous but recent activation of the same engram. The state of excitability of engram cells mediates differential behavioral outcomes upon memory retrieval and may be crucial for survival by promoting adaptive behavior. 2020-07-20T19:52:43Z 2020-07-20T19:52:43Z 2019-01 2018-10 2020-07-16T17:14:25Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 https://hdl.handle.net/1721.1/126263 Pignatelli, Michele et al. "Engram Cell Excitability State Determines the Efficacy of Memory Retrieval." Neuron 101, 2 (January 2019): P274-284.e5 © 2018 Elsevier Inc en http://dx.doi.org/10.1016/j.neuron.2018.11.029 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Pignatelli di Spinazzola, Michele Rivera, Tomás Roy, Dheeraj Lovett, Chanel W. L. Smith, Lillian Muralidhar, Shruti Tonegawa, Susumu Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title | Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title_full | Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title_fullStr | Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title_full_unstemmed | Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title_short | Engram Cell Excitability State Determines the Efficacy of Memory Retrieval |
| title_sort | engram cell excitability state determines the efficacy of memory retrieval |
| url | https://hdl.handle.net/1721.1/126263 |
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