The role of engram cells in the systems consolidation of memory
What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of m...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/126264 |
| _version_ | 1811074519504257024 |
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| author | Tonegawa, Susumu Morrissey, Mark Kitamura, Takashi |
| author2 | RIKEN-MIT Center for Neural Circuit Genetics |
| author_facet | RIKEN-MIT Center for Neural Circuit Genetics Tonegawa, Susumu Morrissey, Mark Kitamura, Takashi |
| author_sort | Tonegawa, Susumu |
| collection | MIT |
| description | What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain. |
| first_indexed | 2024-09-23T09:51:05Z |
| format | Article |
| id | mit-1721.1/126264 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:51:05Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1262642022-09-26T14:06:28Z The role of engram cells in the systems consolidation of memory Tonegawa, Susumu Morrissey, Mark Kitamura, Takashi RIKEN-MIT Center for Neural Circuit Genetics Picower Institute for Learning and Memory Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Biology What happens to memories as days, weeks and years go by has long been a fundamental question in neuroscience and psychology. For decades, researchers have attempted to identify the brain regions in which memory is formed and to follow its changes across time. The theory of systems consolidation of memory (SCM) suggests that changes in circuitry and brain networks are required for the maintenance of a memory with time. Various mechanisms by which such changes may take place have been hypothesized. Recently, several studies have provided insight into the brain networks driving SCM through the characterization of memory engram cells, their biochemical and physiological changes and the circuits in which they operate. In this Review, we place these findings in the context of the field and describe how they have led to a revamped understanding of SCM in the brain. 2020-07-20T20:01:21Z 2020-07-20T20:01:21Z 2018-07 2020-07-16T17:28:52Z Article http://purl.org/eprint/type/JournalArticle 1471-003X 1471-0048 https://hdl.handle.net/1721.1/126264 Tonegawa, Susumu et al. "The role of engram cells in the systems consolidation of memory." Nature Reviews Neuroscience 19, 8 (July 2018): 485–498 © 2018 Macmillan Publishers Ltd., part of Springer Nature en http://dx.doi.org/10.1038/s41583-018-0031-2 Nature Reviews Neuroscience Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer Science and Business Media LLC Prof. Tonegawa via Courtney Crummett |
| spellingShingle | Tonegawa, Susumu Morrissey, Mark Kitamura, Takashi The role of engram cells in the systems consolidation of memory |
| title | The role of engram cells in the systems consolidation of memory |
| title_full | The role of engram cells in the systems consolidation of memory |
| title_fullStr | The role of engram cells in the systems consolidation of memory |
| title_full_unstemmed | The role of engram cells in the systems consolidation of memory |
| title_short | The role of engram cells in the systems consolidation of memory |
| title_sort | role of engram cells in the systems consolidation of memory |
| url | https://hdl.handle.net/1721.1/126264 |
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