Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA

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Chemical modification of transcripts with 5' caps occurs in all organisms. Here, we report a systems-level mass spectrometry-based technique, CapQuant, for quantitative analysis of an organism's cap epitranscriptome. The method was piloted with 21 canonical caps-m7GpppN, m7GpppNm, GpppN, G...

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Bibliographic Details
Main Authors: Wang, Jin, Alvin Chew, Bing Liang, Lai, Yong, Dong, Hongping, Xu, Luang, Balamkundu, Seetharamsingh, Cai, Weiling Maggie, Cui, Liang, Liu, Chuan Fa, Fu, Xin-Yuan, Lin, Zhenguo, Shi, Pei-Yong, Lu, Timothy K, Luo, Dahai, Jaffrey, Samie R, Dedon, Peter C
Other Authors: Massachusetts Institute of Technology. Synthetic Biology Center
Format: Article
Language:English
Published: Oxford University Press (OUP) 2020
Online Access:https://hdl.handle.net/1721.1/126288

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