Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles
Published with license by Taylor & Francis Group, LLC. Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with hos...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Informa UK Limited
2020
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| Online Access: | https://hdl.handle.net/1721.1/126293 |
| _version_ | 1826188394132144128 |
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| author | Sinha, Trishla Vich Vila, Arnau Garmaeva, Sanzhima Jankipersadsing, Soesma A. Imhann, Floris Collij, Valerie Bonder, Marc Jan Jiang, Xiaofang Gurry, Thomas Jerome Alm, Eric J D’Amato, Mauro Weersma, Rinse K. Scherjon, Sicco Wijmenga, Cisca Fu, Jingyuan Kurilshikov, Alexander Zhernakova, Alexandra |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Sinha, Trishla Vich Vila, Arnau Garmaeva, Sanzhima Jankipersadsing, Soesma A. Imhann, Floris Collij, Valerie Bonder, Marc Jan Jiang, Xiaofang Gurry, Thomas Jerome Alm, Eric J D’Amato, Mauro Weersma, Rinse K. Scherjon, Sicco Wijmenga, Cisca Fu, Jingyuan Kurilshikov, Alexander Zhernakova, Alexandra |
| author_sort | Sinha, Trishla |
| collection | MIT |
| description | Published with license by Taylor & Francis Group, LLC. Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with host immune system, sex hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition in 1135 individuals from a population-based cohort. The overall gut microbiome composition of females and males was significantly different (p = 0.001), with females showing a greater microbial diversity (p = 0.009). After correcting for the effects of intrinsic factors, smoking, diet and medications, female hormonal factors such as the use of oral contraceptives and undergoing an ovariectomy were associated with microbial species and pathways. Females had a higher richness of antibiotic-resistance genes, with the most notable being resistance to the lincosamide nucleotidyltransferase (LNU) gene family. The higher abundance of resistance genes is consistent with the greater prescription of the Macrolide-Lincosamide-Streptogramin classes of antibiotics to females. Furthermore, we observed an increased resistance to aminoglycosides in females with self-reported irritable bowel syndrome. These results throw light upon the effects of common medications that are differentially prescribed between sexes and highlight the importance of sex-specific analysis when studying the gut microbiome and resistome. |
| first_indexed | 2024-09-23T07:58:58Z |
| format | Article |
| id | mit-1721.1/126293 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T07:58:58Z |
| publishDate | 2020 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1262932022-09-30T01:29:31Z Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles Sinha, Trishla Vich Vila, Arnau Garmaeva, Sanzhima Jankipersadsing, Soesma A. Imhann, Floris Collij, Valerie Bonder, Marc Jan Jiang, Xiaofang Gurry, Thomas Jerome Alm, Eric J D’Amato, Mauro Weersma, Rinse K. Scherjon, Sicco Wijmenga, Cisca Fu, Jingyuan Kurilshikov, Alexander Zhernakova, Alexandra Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Center for Microbiome Informatics and Therapeutics Broad Institute of MIT and Harvard Massachusetts Institute of Technology. Department of Civil and Environmental Engineering Published with license by Taylor & Francis Group, LLC. Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with host immune system, sex hormones, medication and other environmental factors. Here we performed sex-specific analyses of fecal microbiota composition in 1135 individuals from a population-based cohort. The overall gut microbiome composition of females and males was significantly different (p = 0.001), with females showing a greater microbial diversity (p = 0.009). After correcting for the effects of intrinsic factors, smoking, diet and medications, female hormonal factors such as the use of oral contraceptives and undergoing an ovariectomy were associated with microbial species and pathways. Females had a higher richness of antibiotic-resistance genes, with the most notable being resistance to the lincosamide nucleotidyltransferase (LNU) gene family. The higher abundance of resistance genes is consistent with the greater prescription of the Macrolide-Lincosamide-Streptogramin classes of antibiotics to females. Furthermore, we observed an increased resistance to aminoglycosides in females with self-reported irritable bowel syndrome. These results throw light upon the effects of common medications that are differentially prescribed between sexes and highlight the importance of sex-specific analysis when studying the gut microbiome and resistome. 2020-07-21T20:03:26Z 2020-07-21T20:03:26Z 2018-10 2018-08 2020-03-04T15:46:10Z Article http://purl.org/eprint/type/JournalArticle 1949-0976 1949-0984 https://hdl.handle.net/1721.1/126293 Sinha, Trishla et al. "Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles." Gut Microbes 10, 3 (October 2018): 358-366 © 2018 The Author(s) en http://dx.doi.org/10.1080/19490976.2018.1528822 Gut Microbes Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Informa UK Limited Taylor & Francis |
| spellingShingle | Sinha, Trishla Vich Vila, Arnau Garmaeva, Sanzhima Jankipersadsing, Soesma A. Imhann, Floris Collij, Valerie Bonder, Marc Jan Jiang, Xiaofang Gurry, Thomas Jerome Alm, Eric J D’Amato, Mauro Weersma, Rinse K. Scherjon, Sicco Wijmenga, Cisca Fu, Jingyuan Kurilshikov, Alexander Zhernakova, Alexandra Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title | Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title_full | Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title_fullStr | Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title_full_unstemmed | Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title_short | Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles |
| title_sort | analysis of 1135 gut metagenomes identifies sex specific resistome profiles |
| url | https://hdl.handle.net/1721.1/126293 |
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