Transmission of human-associated microbiota along family and social networks
The human microbiome, described as an accessory organ because of the crucial functions it provides, is composed of species that are uniquely found in humans1,2. Yet, surprisingly little is known about the impact of routine interpersonal contacts in shaping microbiome composition. In a relatively ‘cl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/126322 |
| _version_ | 1826192286410604544 |
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| author | Brito, Ilana L. Gurry, Thomas Jerome Zhao, Shijie Huang, Katherine Young, Sarah K. Shea, Terrence P. Naisilisili, Waisea Jenkins, Aaron P. Jupiter, Stacy D. Gevers, Dirk Alm, Eric J |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Brito, Ilana L. Gurry, Thomas Jerome Zhao, Shijie Huang, Katherine Young, Sarah K. Shea, Terrence P. Naisilisili, Waisea Jenkins, Aaron P. Jupiter, Stacy D. Gevers, Dirk Alm, Eric J |
| author_sort | Brito, Ilana L. |
| collection | MIT |
| description | The human microbiome, described as an accessory organ because of the crucial functions it provides, is composed of species that are uniquely found in humans1,2. Yet, surprisingly little is known about the impact of routine interpersonal contacts in shaping microbiome composition. In a relatively ‘closed’ cohort of 287 people from the Fiji Islands, where common barriers to bacterial transmission are absent, we examine putative bacterial transmission in individuals’ gut and oral microbiomes using strain-level data from both core single-nucleotide polymorphisms and flexible genomic regions. We find a weak signal of transmission, defined by the inferred sharing of genotypes, across many organisms that, in aggregate, reveals strong transmission patterns, most notably within households and between spouses. We were unable to determine the directionality of transmission nor whether it was direct. We further find that women harbour strains more closely related to those harboured by their familial and social contacts than men, and that transmission patterns of oral-associated and gut-associated microbiota need not be the same. Using strain-level data alone, we are able to confidently predict a subset of spouses, highlighting the role of shared susceptibilities, behaviours or social interactions that distinguish specific links in the social network. |
| first_indexed | 2024-09-23T09:09:10Z |
| format | Article |
| id | mit-1721.1/126322 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:09:10Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1263222022-09-30T13:49:19Z Transmission of human-associated microbiota along family and social networks Brito, Ilana L. Gurry, Thomas Jerome Zhao, Shijie Huang, Katherine Young, Sarah K. Shea, Terrence P. Naisilisili, Waisea Jenkins, Aaron P. Jupiter, Stacy D. Gevers, Dirk Alm, Eric J Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Civil and Environmental Engineering The human microbiome, described as an accessory organ because of the crucial functions it provides, is composed of species that are uniquely found in humans1,2. Yet, surprisingly little is known about the impact of routine interpersonal contacts in shaping microbiome composition. In a relatively ‘closed’ cohort of 287 people from the Fiji Islands, where common barriers to bacterial transmission are absent, we examine putative bacterial transmission in individuals’ gut and oral microbiomes using strain-level data from both core single-nucleotide polymorphisms and flexible genomic regions. We find a weak signal of transmission, defined by the inferred sharing of genotypes, across many organisms that, in aggregate, reveals strong transmission patterns, most notably within households and between spouses. We were unable to determine the directionality of transmission nor whether it was direct. We further find that women harbour strains more closely related to those harboured by their familial and social contacts than men, and that transmission patterns of oral-associated and gut-associated microbiota need not be the same. Using strain-level data alone, we are able to confidently predict a subset of spouses, highlighting the role of shared susceptibilities, behaviours or social interactions that distinguish specific links in the social network. 2020-07-22T19:11:40Z 2020-07-22T19:11:40Z 2019-03 2018-07 2020-03-04T15:14:58Z Article http://purl.org/eprint/type/JournalArticle 2058-5276 https://hdl.handle.net/1721.1/126322 Brito, Ilana L. "Transmission of human-associated microbiota along family and social networks." Nature Microbiology 4, 6 (March 2019): 964–971 © 2019 The Author(s) en http://dx.doi.org/10.1038/s41564-019-0409-6 Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Science and Business Media LLC bioRxiv |
| spellingShingle | Brito, Ilana L. Gurry, Thomas Jerome Zhao, Shijie Huang, Katherine Young, Sarah K. Shea, Terrence P. Naisilisili, Waisea Jenkins, Aaron P. Jupiter, Stacy D. Gevers, Dirk Alm, Eric J Transmission of human-associated microbiota along family and social networks |
| title | Transmission of human-associated microbiota along family and social networks |
| title_full | Transmission of human-associated microbiota along family and social networks |
| title_fullStr | Transmission of human-associated microbiota along family and social networks |
| title_full_unstemmed | Transmission of human-associated microbiota along family and social networks |
| title_short | Transmission of human-associated microbiota along family and social networks |
| title_sort | transmission of human associated microbiota along family and social networks |
| url | https://hdl.handle.net/1721.1/126322 |
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