Vitamin B 12 in the spotlight again
April 2017 issue of Current Opinion in Chemical Biology is a special issue: "Biocatalysis & biotransformation * Bioinorganic Chemistry"
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126368 |
| _version_ | 1811074813344612352 |
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| author | Bridwell-Rabb, Jennifer Drennan, Catherine L |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Bridwell-Rabb, Jennifer Drennan, Catherine L |
| author_sort | Bridwell-Rabb, Jennifer |
| collection | MIT |
| description | April 2017 issue of Current Opinion in Chemical Biology is a special issue: "Biocatalysis & biotransformation * Bioinorganic Chemistry" |
| first_indexed | 2024-09-23T09:55:55Z |
| format | Article |
| id | mit-1721.1/126368 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:55:55Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1263682022-09-26T14:39:57Z Vitamin B 12 in the spotlight again Vitamin B[subscript 12] in the spotlight again Bridwell-Rabb, Jennifer Drennan, Catherine L Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Biology April 2017 issue of Current Opinion in Chemical Biology is a special issue: "Biocatalysis & biotransformation * Bioinorganic Chemistry" The ability of cobalamin to coordinate different upper axial ligands gives rise to a diversity of reactivity. Traditionally, adenosylcobalamin is associated with radical-based rearrangements, and methylcobalamin with methyl cation transfers. Recently, however, a new role for adenosylcobalamin has been discovered as a light sensor, and a methylcobalamin-dependent enzyme has been identified that is suggested to transfer a methyl anion. Additionally, recent studies have provided a wealth of new information about a third class of cobalamin-dependent enzymes that do not appear to use an upper ligand. They function in reductive dehalogenations and epoxide reduction reactions. Finally, mechanistic details are beginning to emerge about the cobalamin-dependent S-adenosylmethionine radical enzyme superfamily for which the role of cobalamin has been largely enigmatic. ©2017 Elsevier Ltd National Institute of Health (Grant no. R01-GM69857) National Institute of Health Grant (F32-GM108189) 2020-07-23T21:23:11Z 2020-07-23T21:23:11Z 2017-02 2019-09-18T12:45:02Z Article http://purl.org/eprint/type/JournalArticle 1879-0402 https://hdl.handle.net/1721.1/126368 Bridwell-Rabb, Jennifer and Catherine L. Drennan, "Vitamin B12 in the spotlight again." Current Opinion in Chemical Biology 37 (April 2017): p. 63-70 doi. 10.1016/j.cbpa.2017.01.013 ©2017 Authors en https://dx.doi.org/10.1016/J.CBPA.2017.01.013 Current Opinion in Chemical Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Bridwell-Rabb, Jennifer Drennan, Catherine L Vitamin B 12 in the spotlight again |
| title | Vitamin B 12 in the spotlight again |
| title_full | Vitamin B 12 in the spotlight again |
| title_fullStr | Vitamin B 12 in the spotlight again |
| title_full_unstemmed | Vitamin B 12 in the spotlight again |
| title_short | Vitamin B 12 in the spotlight again |
| title_sort | vitamin b 12 in the spotlight again |
| url | https://hdl.handle.net/1721.1/126368 |
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