Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling

Discovery of proteins associated with a predefined genomic locus via dCas9–APEX-mediated proximity labeling

Regulation of gene expression is primarily controlled by changes in the proteins that occupy genes' regulatory elements. We developed genomic locus proteomics (GLoPro), in which we combine CRISPR-based genome targeting, proximity labeling, and quantitative proteomics to discover proteins associ...

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Bibliographic Details
Main Authors: Myers, Samuel A., Wright, Jason, Peckner, Ryan, Kalish, Brian T., Zhang, Feng, Carr, Steven A
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/126374

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