A cytosine deaminase for programmable single-base RNA editing

A cytosine deaminase for programmable single-base RNA editing

Programmable RNA editing enables reversible recoding of RNA information for research and disease treatment. Previously, we developed a programmable adenosine-to-inosine (A-to-I) RNA editing approach by fusing catalytically inactivate RNA-targeting CRISPR-Cas13 (dCas13) with the adenine deaminase dom...

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Bibliographic Details
Main Authors: Abudayyeh, Omar O., Gootenberg, Jonathan S, Franklin, Brian, Koob, Jeremy, Kellner, Max J., Ladha, Alim, Joung, Julia, Kirchgatterer, Paul, Cox, David B. T., Zhang, Feng
Other Authors: McGovern Institute for Brain Research at MIT
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2020
Online Access:https://hdl.handle.net/1721.1/126395

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