REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease

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The molecular basis of the earliest neuronal changes that lead to Alzheimer’s disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural progenitor (N...

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Bibliographic Details
Main Authors: Meyer, Katharina, Feldman, Heather M., Lu, Tao, Drake, Derek, Lim, Elaine T., Ling, King-Hwa, Bishop, Nicholas A., Pan, Ying, Seo, Jinsoo, Lin, Yuan-Ta, Su, Susan C. (Susan Chih-Chieh), Church, George M., Tsai, Li-Huei, Yankner, Bruce A.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126408

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