A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound a...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Epstein-Barash, Hila, Orbey, Gizem, Polat, Baris E., Ewoldt, Randy H., Feshitan, Jameel, Langer, Robert S, Borden, Mark A., Kohane, Daniel S
Weitere Verfasser: Harvard University--MIT Division of Health Sciences and Technology
Format: Artikel
Sprache:English
Veröffentlicht: Elsevier BV 2020
Online Zugang:https://hdl.handle.net/1721.1/126409
Beschreibung
Zusammenfassung:Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo. ©2010 Elsevier Ltd.

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