Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury
The success of devices delivering functional electrical stimulation (FES) has been hindered by complications related to implants including skin breakdown and subsequent wound dehiscence. Our hypothesis was that a vascularized muscle flap along the dorsal surface of an epimysial electrode would preve...
| Main Authors: | , , , , , |
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Frontiers Media SA
2020
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| Online Access: | https://hdl.handle.net/1721.1/126413 |
| _version_ | 1826201035672125440 |
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| author | McAvoy, Malia Doloff, Joshua C. Khan, Omar F. Rosen, Joseph Langer, Robert S Anderson, Daniel G |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering McAvoy, Malia Doloff, Joshua C. Khan, Omar F. Rosen, Joseph Langer, Robert S Anderson, Daniel G |
| author_sort | McAvoy, Malia |
| collection | MIT |
| description | The success of devices delivering functional electrical stimulation (FES) has been hindered by complications related to implants including skin breakdown and subsequent wound dehiscence. Our hypothesis was that a vascularized muscle flap along the dorsal surface of an epimysial electrode would prevent skin breakdown during FES therapy to treat atrophy of the gastrocnemius muscle during peripheral nerve injury. Resection of a tibial nerve segment with subsequent electrode implantation on the dorsal surfaces of the gastrocnemius muscle was performed on ten Lewis rats. In five rats, the biceps femoris (BF) muscle was dissected and placed along the dorsal surface of the electrode (Flap group). The other five animals did not undergo flap placement (No Flap group). All animals were treated with daily FES therapy for 2 weeks and degree of immune response and skin breakdown were evaluated. The postoperative course of one animal in the No Flap group was complicated by complete wound dehiscence requiring euthanasia of the animal on postoperative day 4. The remaining 4 No Flap animals showed evidence of ulceration at the implant by postoperative day 7. The 5 animals in the Flap group did not have ulcerative lesions. Excised tissue at postoperative day 14 examined by histology and in vivo Imaging System (IVIS) showed decreased implant-induced inflammation in the Flap group. Expression of specific markers for local foreign body response were also decreased in the Flap group. |
| first_indexed | 2024-09-23T11:45:38Z |
| format | Article |
| id | mit-1721.1/126413 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T11:45:38Z |
| publishDate | 2020 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1264132022-09-27T21:44:59Z Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury McAvoy, Malia Doloff, Joshua C. Khan, Omar F. Rosen, Joseph Langer, Robert S Anderson, Daniel G Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Koch Institute for Integrative Cancer Research at MIT The success of devices delivering functional electrical stimulation (FES) has been hindered by complications related to implants including skin breakdown and subsequent wound dehiscence. Our hypothesis was that a vascularized muscle flap along the dorsal surface of an epimysial electrode would prevent skin breakdown during FES therapy to treat atrophy of the gastrocnemius muscle during peripheral nerve injury. Resection of a tibial nerve segment with subsequent electrode implantation on the dorsal surfaces of the gastrocnemius muscle was performed on ten Lewis rats. In five rats, the biceps femoris (BF) muscle was dissected and placed along the dorsal surface of the electrode (Flap group). The other five animals did not undergo flap placement (No Flap group). All animals were treated with daily FES therapy for 2 weeks and degree of immune response and skin breakdown were evaluated. The postoperative course of one animal in the No Flap group was complicated by complete wound dehiscence requiring euthanasia of the animal on postoperative day 4. The remaining 4 No Flap animals showed evidence of ulceration at the implant by postoperative day 7. The 5 animals in the Flap group did not have ulcerative lesions. Excised tissue at postoperative day 14 examined by histology and in vivo Imaging System (IVIS) showed decreased implant-induced inflammation in the Flap group. Expression of specific markers for local foreign body response were also decreased in the Flap group. Armed Forces Institute of Regenerative Medicine (Grant W81XWH-08-2-0034) National Cancer Institute (Grant P30-CA14051) 2020-07-28T15:55:18Z 2020-07-28T15:55:18Z 2020-07 2020-04 Article http://purl.org/eprint/type/JournalArticle 1664-2295 https://hdl.handle.net/1721.1/126413 McAvoy, Malia et al. "Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury." Frontiers in Neurology 11 (July 2020): 644 © 2020 The Authors http://dx.doi.org/10.3389/fneur.2020.00644 Frontiers in Neurology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | McAvoy, Malia Doloff, Joshua C. Khan, Omar F. Rosen, Joseph Langer, Robert S Anderson, Daniel G Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title | Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title_full | Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title_fullStr | Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title_full_unstemmed | Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title_short | Vascularized Muscle Flap to Reduce Wound Breakdown During Flexible Electrode-Mediated Functional Electrical Stimulation After Peripheral Nerve Injury |
| title_sort | vascularized muscle flap to reduce wound breakdown during flexible electrode mediated functional electrical stimulation after peripheral nerve injury |
| url | https://hdl.handle.net/1721.1/126413 |
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