Microfluidics in structured multimaterial fibers
Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, pie...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Proceedings of the National Academy of Sciences
2020
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| Online Access: | https://hdl.handle.net/1721.1/126427 |
| _version_ | 1826211863850909696 |
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| author | Yuan, Rodger Lee, Jaemyon Su, Hao-Wei Levy, Etgar Claude Khudiyev, Tural Voldman, Joel Fink, Yoel |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Yuan, Rodger Lee, Jaemyon Su, Hao-Wei Levy, Etgar Claude Khudiyev, Tural Voldman, Joel Fink, Yoel |
| author_sort | Yuan, Rodger |
| collection | MIT |
| description | Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here we report a method of fabricating microfluidic channels with complex cross-sections. A scaled-up version of a microchannel is dimensionally reduced through a thermal drawing process, enabling the fabrication of meters-long microfluidic fibers with nonrectangular cross-sectional shapes, such as crosses, five-pointed stars, and crescents. In addition, by codrawing compatible materials, conductive domains can be integrated at arbitrary locations along channel walls. We validate this technology by studying unexplored regimes in hydrodynamic flow and by designing a high-throughput cell separation device. By enabling these degrees of freedom in microfluidic device design, fiber microfluidics provides a method to create microchannel designs that are inaccessible using planar techniques. ©2018 |
| first_indexed | 2024-09-23T15:12:20Z |
| format | Article |
| id | mit-1721.1/126427 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:12:20Z |
| publishDate | 2020 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1264272022-10-02T01:21:01Z Microfluidics in structured multimaterial fibers Yuan, Rodger Lee, Jaemyon Su, Hao-Wei Levy, Etgar Claude Khudiyev, Tural Voldman, Joel Fink, Yoel Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Microsystems Technology Laboratories Traditional fabrication techniques for microfluidic devices utilize a planar chip format that possesses limited control over the geometry of and materials placement around microchannel cross-sections. This imposes restrictions on the design of flow fields and external forces (electric, magnetic, piezoelectric, etc.) that can be imposed onto fluids and particles. Here we report a method of fabricating microfluidic channels with complex cross-sections. A scaled-up version of a microchannel is dimensionally reduced through a thermal drawing process, enabling the fabrication of meters-long microfluidic fibers with nonrectangular cross-sectional shapes, such as crosses, five-pointed stars, and crescents. In addition, by codrawing compatible materials, conductive domains can be integrated at arbitrary locations along channel walls. We validate this technology by studying unexplored regimes in hydrodynamic flow and by designing a high-throughput cell separation device. By enabling these degrees of freedom in microfluidic device design, fiber microfluidics provides a method to create microchannel designs that are inaccessible using planar techniques. ©2018 NSF - Center for Materials Science and Engineering (DMR-0819762) NSF - Center for Materials Science and Engineering (DMR-1419807) US Army Research Lab. & the US Army Research Office through the Institute for Soldier Nanotechnologies (Contract W911NF-13-D-0001) NIH (Contract 1R21EB022729). Defense Advanced Research Projects Agency (Contract N66001-11-1-4182) NIH (Contract (1U24AI118656) NIH (Contract 1R21EB022729) 2020-07-28T22:29:40Z 2020-07-28T22:29:40Z 2018-10 2018-06 2019-09-16T14:03:18Z Article http://purl.org/eprint/type/JournalArticle 1091-6490 https://hdl.handle.net/1721.1/126427 Yuan, Rodger et al., "Microfluidics in structured multimaterial fibers." Proceedings of the National Academy of Sciences of the United States of America 115, 46 (November 2018): p. E10830-E10838 doi. 10.1073/pnas.1809459115 ©2018 Authors en https://dx.doi.org/10.1073/PNAS.1809459115 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Yuan, Rodger Lee, Jaemyon Su, Hao-Wei Levy, Etgar Claude Khudiyev, Tural Voldman, Joel Fink, Yoel Microfluidics in structured multimaterial fibers |
| title | Microfluidics in structured multimaterial fibers |
| title_full | Microfluidics in structured multimaterial fibers |
| title_fullStr | Microfluidics in structured multimaterial fibers |
| title_full_unstemmed | Microfluidics in structured multimaterial fibers |
| title_short | Microfluidics in structured multimaterial fibers |
| title_sort | microfluidics in structured multimaterial fibers |
| url | https://hdl.handle.net/1721.1/126427 |
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