Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood
Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analys...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press (OUP)
2020
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| Online Access: | https://hdl.handle.net/1721.1/126433 |
| _version_ | 1811083240135458816 |
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| author | Park, Anne T Leonard, Julia Anne Saxler, Patricia Kasak Cyr, Abigail B. Gabrieli, John D. E. Mackey, Allyson P |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Park, Anne T Leonard, Julia Anne Saxler, Patricia Kasak Cyr, Abigail B. Gabrieli, John D. E. Mackey, Allyson P |
| author_sort | Park, Anne T |
| collection | MIT |
| description | Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to seven-year-old children, we found a significant correlation between more adverse experiences and weaker amygdala-mPFC rs-FC. We also found that weaker amygdala-mPFC rs-FC was associated with higher levels of aggressive behavior and attention problems. These findings suggest that the impact of stress on emotional circuitry is detectable in early childhood and that this impact is associated with mental health difficulties. Connectivity in this circuit may be useful as a marker for mental health risk and for tracking the efficacy of early interventions. |
| first_indexed | 2024-09-23T12:29:24Z |
| format | Article |
| id | mit-1721.1/126433 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:29:24Z |
| publishDate | 2020 |
| publisher | Oxford University Press (OUP) |
| record_format | dspace |
| spelling | mit-1721.1/1264332022-09-28T08:08:52Z Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood Park, Anne T Leonard, Julia Anne Saxler, Patricia Kasak Cyr, Abigail B. Gabrieli, John D. E. Mackey, Allyson P McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Early life stress has been associated with disrupted functional connectivity between the amygdala and medial prefrontal cortex (mPFC), but it is unknown how early in development stress-related differences in amygdala-mPFC connectivity emerge. In a resting-state functional connectivity (rs-FC) analysis with 79 four- to seven-year-old children, we found a significant correlation between more adverse experiences and weaker amygdala-mPFC rs-FC. We also found that weaker amygdala-mPFC rs-FC was associated with higher levels of aggressive behavior and attention problems. These findings suggest that the impact of stress on emotional circuitry is detectable in early childhood and that this impact is associated with mental health difficulties. Connectivity in this circuit may be useful as a marker for mental health risk and for tracking the efficacy of early interventions. 2020-07-29T21:39:08Z 2020-07-29T21:39:08Z 2018-03 2018-01 2019-10-01T13:35:28Z Article http://purl.org/eprint/type/JournalArticle 1749-5016 1749-5024 https://hdl.handle.net/1721.1/126433 Park, Anne T. et al. "Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood." Social Cognitive and Affective Neuroscience 13, 4 (March 2018): 430–439 © 2018 The Author(s) en http://dx.doi.org/10.1093/scan/nsy017 Social Cognitive and Affective Neuroscience Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf Oxford University Press (OUP) Oxford University Press |
| spellingShingle | Park, Anne T Leonard, Julia Anne Saxler, Patricia Kasak Cyr, Abigail B. Gabrieli, John D. E. Mackey, Allyson P Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title | Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title_full | Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title_fullStr | Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title_full_unstemmed | Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title_short | Amygdala–medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| title_sort | amygdala medial prefrontal cortex connectivity relates to stress and mental health in early childhood |
| url | https://hdl.handle.net/1721.1/126433 |
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