Dysfunction of Rapid Neural Adaptation in Dyslexia
Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiol...
| Main Authors: | , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126439 |
| _version_ | 1826214787831300096 |
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| author | Perrachione, Tyler Kent Del Tufo, Stephanie Nicole Winter, Rebecca Murtagh, Jack Cyr, Abigail B. Chang, Patricia Halverson, Kelly Ghosh, Satrajit S Christodoulou, Joanna Gabrieli, John D. E. |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Perrachione, Tyler Kent Del Tufo, Stephanie Nicole Winter, Rebecca Murtagh, Jack Cyr, Abigail B. Chang, Patricia Halverson, Kelly Ghosh, Satrajit S Christodoulou, Joanna Gabrieli, John D. E. |
| author_sort | Perrachione, Tyler Kent |
| collection | MIT |
| description | Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiological adaptation to stimulus repetition in adults and children with dyslexia for a wide variety of stimuli, spoken words, written words, visual objects, and faces. For every stimulus type, individuals with dyslexia exhibited significantly diminished neural adaptation compared to controls in stimulus-specific cortical areas. Better reading skills in adults and children with dyslexia were associated with greater repetition-induced neural adaptation. These results highlight a dysfunction of rapid neural adaptation as a core neurophysiological difference in dyslexia that may underlie impaired reading development. Reduced neurophysiological adaptation may relate to prior reports of reduced behavioral adaptation in dyslexia and may reveal a difference in brain functions that ultimately results in a specific reading impairment. |
| first_indexed | 2024-09-23T16:11:08Z |
| format | Article |
| id | mit-1721.1/126439 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:11:08Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1264392022-09-29T18:49:23Z Dysfunction of Rapid Neural Adaptation in Dyslexia Perrachione, Tyler Kent Del Tufo, Stephanie Nicole Winter, Rebecca Murtagh, Jack Cyr, Abigail B. Chang, Patricia Halverson, Kelly Ghosh, Satrajit S Christodoulou, Joanna Gabrieli, John D. E. McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Research Laboratory of Electronics Identification of specific neurophysiological dysfunctions resulting in selective reading difficulty (dyslexia) has remained elusive. In addition to impaired reading development, individuals with dyslexia frequently exhibit behavioral deficits in perceptual adaptation. Here, we assessed neurophysiological adaptation to stimulus repetition in adults and children with dyslexia for a wide variety of stimuli, spoken words, written words, visual objects, and faces. For every stimulus type, individuals with dyslexia exhibited significantly diminished neural adaptation compared to controls in stimulus-specific cortical areas. Better reading skills in adults and children with dyslexia were associated with greater repetition-induced neural adaptation. These results highlight a dysfunction of rapid neural adaptation as a core neurophysiological difference in dyslexia that may underlie impaired reading development. Reduced neurophysiological adaptation may relate to prior reports of reduced behavioral adaptation in dyslexia and may reveal a difference in brain functions that ultimately results in a specific reading impairment. NIH (Grant UL1RR025758) 2020-07-30T00:44:04Z 2020-07-30T00:44:04Z 2016-12 2016-08 2019-10-01T13:25:54Z Article http://purl.org/eprint/type/JournalArticle 0896-6273 https://hdl.handle.net/1721.1/126439 Perrachione, Tyler K. et al. "Dysfunction of Rapid Neural Adaptation in Dyslexia." Neuron 92, 6 (December 2016): P1383-1397 © 2016 Elsevier Inc en http://dx.doi.org/10.1016/j.neuron.2016.11.020 Neuron Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Perrachione, Tyler Kent Del Tufo, Stephanie Nicole Winter, Rebecca Murtagh, Jack Cyr, Abigail B. Chang, Patricia Halverson, Kelly Ghosh, Satrajit S Christodoulou, Joanna Gabrieli, John D. E. Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title | Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title_full | Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title_fullStr | Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title_full_unstemmed | Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title_short | Dysfunction of Rapid Neural Adaptation in Dyslexia |
| title_sort | dysfunction of rapid neural adaptation in dyslexia |
| url | https://hdl.handle.net/1721.1/126439 |
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