Controlling timing and location in vaccines
Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence o...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/126473 |
| _version_ | 1826204096125730816 |
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| author | Irvine, Darrell J Aung, Aereas Silva, Murillo |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Irvine, Darrell J Aung, Aereas Silva, Murillo |
| author_sort | Irvine, Darrell J |
| collection | MIT |
| description | Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence of antigen and inflammatory cues for an appropriate temporal duration within the lymph nodes, and further within appropriate subcompartments of the lymph nodes– the right timing and location– play a critical role in shaping cellular and humoral immunity. Here we review recent advances in our understanding of how vaccine kinetics and biodistribution impact adaptive immunity, and the underlying immunological mechanisms that govern these responses. We discuss emerging approaches to engineer these properties for future vaccines, with a focus on subunit vaccines. |
| first_indexed | 2024-09-23T12:48:50Z |
| format | Article |
| id | mit-1721.1/126473 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:48:50Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1264732022-10-01T11:17:21Z Controlling timing and location in vaccines Irvine, Darrell J Aung, Aereas Silva, Murillo Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Koch Institute for Integrative Cancer Research at MIT Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence of antigen and inflammatory cues for an appropriate temporal duration within the lymph nodes, and further within appropriate subcompartments of the lymph nodes– the right timing and location– play a critical role in shaping cellular and humoral immunity. Here we review recent advances in our understanding of how vaccine kinetics and biodistribution impact adaptive immunity, and the underlying immunological mechanisms that govern these responses. We discuss emerging approaches to engineer these properties for future vaccines, with a focus on subunit vaccines. 2020-08-05T15:32:11Z 2020-08-05T15:32:11Z 2020-06 2020-06 2020-08-04T14:49:39Z Article http://purl.org/eprint/type/JournalArticle 0169-409X https://hdl.handle.net/1721.1/126473 Irvine, Darrell J. et al. "Controlling timing and location in vaccines." Forthcoming in Advanced Drug Delivery Reviews (June 2020): http://dx.doi.org/10.1016/j.addr.2020.06.019 © 2020 The Authors en http://dx.doi.org/10.1016/j.addr.2020.06.019 Advanced Drug Delivery Reviews Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Irvine, Darrell J Aung, Aereas Silva, Murillo Controlling timing and location in vaccines |
| title | Controlling timing and location in vaccines |
| title_full | Controlling timing and location in vaccines |
| title_fullStr | Controlling timing and location in vaccines |
| title_full_unstemmed | Controlling timing and location in vaccines |
| title_short | Controlling timing and location in vaccines |
| title_sort | controlling timing and location in vaccines |
| url | https://hdl.handle.net/1721.1/126473 |
| work_keys_str_mv | AT irvinedarrellj controllingtimingandlocationinvaccines AT aungaereas controllingtimingandlocationinvaccines AT silvamurillo controllingtimingandlocationinvaccines |