A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images
Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Institute of Electrical and Electronics Engineers (IEEE)
2020
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| Online Access: | https://hdl.handle.net/1721.1/126586 |
| _version_ | 1826190713983860736 |
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| author | Olender, Max Athanasiou, Lambros S. Hernández, José M. de la Torre Ben-Assa, Eyal Rikhtegar Nezami, Farhad Edelman, Elazer R |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Olender, Max Athanasiou, Lambros S. Hernández, José M. de la Torre Ben-Assa, Eyal Rikhtegar Nezami, Farhad Edelman, Elazer R |
| author_sort | Olender, Max |
| collection | MIT |
| description | Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to the limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly spaced and sometimes unreliably identified visible segments of the vessel outer border. This paper describes an intuitive, efficient, and flexible new method of 3D surface fitting and smoothing suitable for this task. An anisotropic linear-elastic mesh is fit to irregularly spaced and uncertain data points corresponding to visible segments of vessel borders, enabling the fully automated delineation of the entire inner and outer borders of diseased vessels in OCT images for the first time. In a clinical dataset, the proposed smooth surface fitting approach had great agreement when compared with human annotations: areas differed by just 11 ± 11% (0.93 ± 0.84 mm2), with a coefficient of determination of 0.89. Overlapping and non-overlapping area ratios were 0.91 and 0.18, respectively, with a sensitivity of 90.8 and specificity of 99.0. This spring mesh method of contour fitting significantly outperformed all alternative surface fitting and interpolation approaches tested. The application of this promising proposed method is expected to enhance clinical intervention and translational research using OCT. |
| first_indexed | 2024-09-23T08:44:15Z |
| format | Article |
| id | mit-1721.1/126586 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:44:15Z |
| publishDate | 2020 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/1265862022-09-23T14:13:28Z A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images Olender, Max Athanasiou, Lambros S. Hernández, José M. de la Torre Ben-Assa, Eyal Rikhtegar Nezami, Farhad Edelman, Elazer R Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Mechanical Engineering Automated analysis of vascular imaging techniques is limited by the inability to precisely determine arterial borders. Intravascular optical coherence tomography (OCT) offers unprecedented detail of artery wall structure and composition, but does not provide consistent visibility of the outer border of the vessel due to the limited penetration depth. Existing interpolation and surface fitting methods prove insufficient to accurately fill the gaps between the irregularly spaced and sometimes unreliably identified visible segments of the vessel outer border. This paper describes an intuitive, efficient, and flexible new method of 3D surface fitting and smoothing suitable for this task. An anisotropic linear-elastic mesh is fit to irregularly spaced and uncertain data points corresponding to visible segments of vessel borders, enabling the fully automated delineation of the entire inner and outer borders of diseased vessels in OCT images for the first time. In a clinical dataset, the proposed smooth surface fitting approach had great agreement when compared with human annotations: areas differed by just 11 ± 11% (0.93 ± 0.84 mm2), with a coefficient of determination of 0.89. Overlapping and non-overlapping area ratios were 0.91 and 0.18, respectively, with a sensitivity of 90.8 and specificity of 99.0. This spring mesh method of contour fitting significantly outperformed all alternative surface fitting and interpolation approaches tested. The application of this promising proposed method is expected to enhance clinical intervention and translational research using OCT. U.S. National Institutes of Health (Grant GM 49039). 2020-08-14T18:30:35Z 2020-08-14T18:30:35Z 2019-06 2019-10-09T17:36:13Z Article http://purl.org/eprint/type/JournalArticle 1558-254X 0278-0062 https://hdl.handle.net/1721.1/126586 Olender, Max L. et al. "A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images." IEEE Transactions on Medical Imaging 38, 6 (June 2019): 1384-1397 ©2019 Author(s) en 10.1109/TMI.2018.2884142 IEEE Transactions on Medical Imaging Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Institute of Electrical and Electronics Engineers (IEEE) PMC |
| spellingShingle | Olender, Max Athanasiou, Lambros S. Hernández, José M. de la Torre Ben-Assa, Eyal Rikhtegar Nezami, Farhad Edelman, Elazer R A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title | A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title_full | A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title_fullStr | A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title_full_unstemmed | A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title_short | A mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| title_sort | mechanical approach for smooth surface fitting to delineate vessel walls in optical coherence tomography images |
| url | https://hdl.handle.net/1721.1/126586 |
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