Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation
We have developed a system that could potentially be used to identify the site of origin of ventricular tachycardia (VT) and to guide a catheter to that site to deliver radio-frequency ablation therapy. This system employs the Inverse Solution Guidance Algorithm based upon Single Equivalent Moving D...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer US
2020
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| Online Access: | https://hdl.handle.net/1721.1/127822 |
| _version_ | 1826199912869527552 |
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| author | Lv, Wener Lee, Kichang Arai, Tatsuya Barrett, Conor D Hasan, Maysun Mazhar Hayward, Alison M Marini, Robert P. Barley, Maya E. Galea, Anna Hirschman, Gordon Armoundas, Antonis A Cohen, Richard J. |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Lv, Wener Lee, Kichang Arai, Tatsuya Barrett, Conor D Hasan, Maysun Mazhar Hayward, Alison M Marini, Robert P. Barley, Maya E. Galea, Anna Hirschman, Gordon Armoundas, Antonis A Cohen, Richard J. |
| author_sort | Lv, Wener |
| collection | MIT |
| description | We have developed a system that could potentially be used to identify the site of origin of ventricular tachycardia (VT) and to guide a catheter to that site to deliver radio-frequency ablation therapy. This system employs the Inverse Solution Guidance Algorithm based upon Single Equivalent Moving Dipole (SEMD) localization method. The system was evaluated in in vivo swine experiments. Arrays consisting of 9 or 16 bipolar epicardial electrodes and an additional mid-myocardial pacing lead were sutured to each ventricle. Focal tachycardia was simulated by applying pacing pulses to each epicardial electrode at multiple pacing rates during breath hold at the end-expiration phase. Surface potentials were recorded from 64 surface electrodes and then analyzed using the SEMD method to localize the position of the pacing electrodes. We found a close correlation between the locations of the pacing electrodes as measured in computational and real spaces. The reproducibility error of the SEMD estimation of electrode location was 0.21 ± 0.07 cm. The vectors between every pair of bipolar electrodes were computed in computational and real spaces. At 120 bpm, the lengths of the vectors in the computational and real space had a 95% correlation. Computational space vectors were used in catheter guidance simulations which showed that this method could reduce the distance between the real space locations of the emulated catheter tip and the emulated arrhythmia origin site by approximately 72% with each movement. We have demonstrated the feasibility of using our system to guide a catheter to the site of the emulated VT origin. |
| first_indexed | 2024-09-23T11:27:47Z |
| format | Article |
| id | mit-1721.1/127822 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:27:47Z |
| publishDate | 2020 |
| publisher | Springer US |
| record_format | dspace |
| spelling | mit-1721.1/1278222022-09-27T19:43:29Z Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation Lv, Wener Lee, Kichang Arai, Tatsuya Barrett, Conor D Hasan, Maysun Mazhar Hayward, Alison M Marini, Robert P. Barley, Maya E. Galea, Anna Hirschman, Gordon Armoundas, Antonis A Cohen, Richard J. Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Aeronautics and Astronautics Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Division of Comparative Medicine Harvard University--MIT Division of Health Sciences and Technology We have developed a system that could potentially be used to identify the site of origin of ventricular tachycardia (VT) and to guide a catheter to that site to deliver radio-frequency ablation therapy. This system employs the Inverse Solution Guidance Algorithm based upon Single Equivalent Moving Dipole (SEMD) localization method. The system was evaluated in in vivo swine experiments. Arrays consisting of 9 or 16 bipolar epicardial electrodes and an additional mid-myocardial pacing lead were sutured to each ventricle. Focal tachycardia was simulated by applying pacing pulses to each epicardial electrode at multiple pacing rates during breath hold at the end-expiration phase. Surface potentials were recorded from 64 surface electrodes and then analyzed using the SEMD method to localize the position of the pacing electrodes. We found a close correlation between the locations of the pacing electrodes as measured in computational and real spaces. The reproducibility error of the SEMD estimation of electrode location was 0.21 ± 0.07 cm. The vectors between every pair of bipolar electrodes were computed in computational and real spaces. At 120 bpm, the lengths of the vectors in the computational and real space had a 95% correlation. Computational space vectors were used in catheter guidance simulations which showed that this method could reduce the distance between the real space locations of the emulated catheter tip and the emulated arrhythmia origin site by approximately 72% with each movement. We have demonstrated the feasibility of using our system to guide a catheter to the site of the emulated VT origin. NIH (grant R44 HL079726-04) 2020-10-07T14:32:22Z 2020-10-07T14:32:22Z 2020-09 2019-01 2020-09-24T21:34:15Z Article http://purl.org/eprint/type/JournalArticle 1572-8595 1383-875X https://hdl.handle.net/1721.1/127822 Lv, Wener et al. "Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation." Journal of Interventional Cardiac Electrophysiology 58 (September 2020): 323-31 ©2020 Author(s) en 10.1007/s10840-019-00605-z Journal of Interventional Cardiac Electrophysiology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer US Springer US |
| spellingShingle | Lv, Wener Lee, Kichang Arai, Tatsuya Barrett, Conor D Hasan, Maysun Mazhar Hayward, Alison M Marini, Robert P. Barley, Maya E. Galea, Anna Hirschman, Gordon Armoundas, Antonis A Cohen, Richard J. Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title | Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title_full | Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title_fullStr | Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title_full_unstemmed | Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title_short | Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| title_sort | accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation |
| url | https://hdl.handle.net/1721.1/127822 |
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