Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine
Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2020
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| Online Access: | https://hdl.handle.net/1721.1/127929 |
| _version_ | 1826211497614770176 |
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| author | Le, Serena. |
| author2 | Alexander H. Slocum. |
| author_facet | Alexander H. Slocum. Le, Serena. |
| author_sort | Le, Serena. |
| collection | MIT |
| description | Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020 |
| first_indexed | 2024-09-23T15:06:53Z |
| format | Thesis |
| id | mit-1721.1/127929 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T15:06:53Z |
| publishDate | 2020 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1279292020-10-09T03:06:42Z Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine Le, Serena. Alexander H. Slocum. Massachusetts Institute of Technology. Department of Mechanical Engineering. Massachusetts Institute of Technology. Department of Mechanical Engineering Mechanical Engineering. Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020 Cataloged from the official PDF of thesis. Includes bibliographical references (pages 65-66). Lyophilization, or freeze drying, of unit-dose pharmaceuticals eliminates the need to preserve quality through regulated temperature storage during transport. Typical lyophilization is performed through batch processing, but implementing continuous manufacturing instead can lead to improved process control, higher quality product, and increased flexibility. Lyophilization involves four processing chambers at specific pressures and transferring vials between the chambers requires a load lock system. Load lock systems, commonly used in the semiconductor industry, act as a transfer chamber in order to reduce pump-down and venting time of its adjacent processing chambers. This thesis documents the research and design of a load lock system for a continuous manufacturing lyophilization machine. by Serena Le. S.B. S.B. Massachusetts Institute of Technology, Department of Mechanical Engineering 2020-10-08T21:30:52Z 2020-10-08T21:30:52Z 2020 2020 Thesis https://hdl.handle.net/1721.1/127929 1197978944 eng MIT theses may be protected by copyright. Please reuse MIT thesis content according to the MIT Libraries Permissions Policy, which is available through the URL provided. http://dspace.mit.edu/handle/1721.1/7582 66 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Mechanical Engineering. Le, Serena. Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title | Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title_full | Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title_fullStr | Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title_full_unstemmed | Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title_short | Design of a load-lock system for the lyophilization of unit-dose pharmaceuticals in a continuous manufacturing machine |
| title_sort | design of a load lock system for the lyophilization of unit dose pharmaceuticals in a continuous manufacturing machine |
| topic | Mechanical Engineering. |
| url | https://hdl.handle.net/1721.1/127929 |
| work_keys_str_mv | AT leserena designofaloadlocksystemforthelyophilizationofunitdosepharmaceuticalsinacontinuousmanufacturingmachine |