Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia
The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the eff...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2020
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| Online Access: | https://hdl.handle.net/1721.1/128267 |
| _version_ | 1811070373707382784 |
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| author | Madireddy, Sahithi |
| author2 | Massachusetts Institute of Technology. Department of Urban Studies and Planning |
| author_facet | Massachusetts Institute of Technology. Department of Urban Studies and Planning Madireddy, Sahithi |
| author_sort | Madireddy, Sahithi |
| collection | MIT |
| description | The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery. |
| first_indexed | 2024-09-23T08:34:56Z |
| format | Article |
| id | mit-1721.1/128267 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T08:34:56Z |
| publishDate | 2020 |
| publisher | Multidisciplinary Digital Publishing Institute |
| record_format | dspace |
| spelling | mit-1721.1/1282672022-09-23T13:04:19Z Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia Madireddy, Sahithi Massachusetts Institute of Technology. Department of Urban Studies and Planning The biochemical integrity of the brain is paramount to the function of the central nervous system, and oxidative stress is a key contributor to cerebral biochemical impairment. Oxidative stress, which occurs when an imbalance arises between the production of reactive oxygen species (ROS) and the efficacy of the antioxidant defense mechanism, is believed to play a role in the pathophysiology of various brain disorders. One such disorder, schizophrenia, not only causes lifelong disability but also induces severe emotional distress; however, because of its onset in early adolescence or adulthood and its progressive development, consuming natural antioxidant products may help regulate the pathogenesis of schizophrenia. Therefore, elucidating the functions of ROS and dietary antioxidants in the pathogenesis of schizophrenia could help formulate improved therapeutic strategies for its prevention and treatment. This review focuses specifically on the roles of ROS and oxidative damage in the pathophysiology of schizophrenia, as well as the effects of nutrition, antipsychotic use, cognitive therapies, and quality of life on patients with schizophrenia. By improving our understanding of the effects of various nutrients on schizophrenia, it may become possible to develop nutritional strategies and supplements to treat the disorder, alleviate its symptoms, and facilitate long-term recovery. 2020-10-30T12:54:29Z 2020-10-30T12:54:29Z 2020-10-16 2020-10 2020-10-26T14:22:11Z Article http://purl.org/eprint/type/JournalArticle 2076-3425 https://hdl.handle.net/1721.1/128267 Madireddy, Samskruthi and Sahithi Madireddy. “Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia.” Brain Sciences, 10, 10 (October 2020): 742 © 2020 The Author(s) Brain Sciences 10 (10): 742 (2020) PUBLISHER_CC http://dx.doi.org/10.3390/brainsci10100742 Brain Sciences Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf Multidisciplinary Digital Publishing Institute Multidisciplinary Digital Publishing Institute |
| spellingShingle | Madireddy, Sahithi Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title_full | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title_fullStr | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title_full_unstemmed | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title_short | Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia |
| title_sort | regulation of reactive oxygen species mediated damage in the pathogenesis of schizophrenia |
| url | https://hdl.handle.net/1721.1/128267 |
| work_keys_str_mv | AT madireddysahithi regulationofreactiveoxygenspeciesmediateddamageinthepathogenesisofschizophrenia |