Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

Germline-Encoded Affinity for Cognate Antigen Enables Vaccine Amplification of a Human Broadly Neutralizing Response against Influenza Virus

Antibody paratopes are formed by hypervariable complementarity-determining regions (CDRH3s) and variable gene-encoded CDRs. The latter show biased usage in human broadly neutralizing antibodies (bnAbs) against both HIV and influenza virus, suggesting the existence of gene-endowed targeting solutions...

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Bibliographic Details
Main Authors: Sangesland, Maya, Ronsard, Larance, Kazer, Samuel Weisgurt, Bals, Julia, Boyoglu-Barnum, Seyhan, Yousif, Ashraf S., Barnes, Ralston, Feldman, Jared, Quirindongo-Crespo, Maricel, McTamney, Patrick M., Rohrer, Daniel, Lonberg, Nils, Chackerian, Bryce, Graham, Barney S., Kanekiyo, Masaru, Shalek, Alexander K, Lingwood, Daniel
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/128273

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