Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers
The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implants because the device loses its fixation strength before the fractured bone heals. This study suggests a new approach to overcome this hurdle by accelerating tissue regeneration...
| Autori principali: | , , , , , , , , , , , , |
|---|---|
| Altri autori: | |
| Natura: | Articolo |
| Lingua: | English |
| Pubblicazione: |
Springer Science and Business Media LLC
2020
|
| Accesso online: | https://hdl.handle.net/1721.1/128430 |
| _version_ | 1826194152358936576 |
|---|---|
| author | Jeon, Jin-Kyung Seo, Hyunseon Park, Jimin Son, Soo Ji Kim, Yeong Rim Kim, Eun Shil Park, Jong Woong Jung, Woong-Gyo Jeon, Hojeong Kim, Yu-Chan Seok, Hyun-Kwang Shin, Jae Ho Ok, Myoung-Ryul |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Jeon, Jin-Kyung Seo, Hyunseon Park, Jimin Son, Soo Ji Kim, Yeong Rim Kim, Eun Shil Park, Jong Woong Jung, Woong-Gyo Jeon, Hojeong Kim, Yu-Chan Seok, Hyun-Kwang Shin, Jae Ho Ok, Myoung-Ryul |
| author_sort | Jeon, Jin-Kyung |
| collection | MIT |
| description | The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implants because the device loses its fixation strength before the fractured bone heals. This study suggests a new approach to overcome this hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is an essential process in early bone regeneration, a Mg implant coated with electrospun nanofibers containing nitric oxide (NO), which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to be stored on the NO donor-conjugated nanofiber coating, stably delivered, and released to the fractured bone tissue near the implanted sites. An in vitro corrosion test reveals no adverse effect of the released NO on the corrosion behavior of the Mg implant. Simultaneously, the optimal concentration level of NO released from the implant significantly enhances tube network formation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis can be accelerated by combining NO-releasing nanofibers with a Mg implant. With its proven feasibility, the proposed approach could be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fixation. |
| first_indexed | 2024-09-23T09:51:44Z |
| format | Article |
| id | mit-1721.1/128430 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:51:44Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1284302022-09-30T17:19:04Z Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers Jeon, Jin-Kyung Seo, Hyunseon Park, Jimin Son, Soo Ji Kim, Yeong Rim Kim, Eun Shil Park, Jong Woong Jung, Woong-Gyo Jeon, Hojeong Kim, Yu-Chan Seok, Hyun-Kwang Shin, Jae Ho Ok, Myoung-Ryul Massachusetts Institute of Technology. Department of Materials Science and Engineering The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implants because the device loses its fixation strength before the fractured bone heals. This study suggests a new approach to overcome this hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is an essential process in early bone regeneration, a Mg implant coated with electrospun nanofibers containing nitric oxide (NO), which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to be stored on the NO donor-conjugated nanofiber coating, stably delivered, and released to the fractured bone tissue near the implanted sites. An in vitro corrosion test reveals no adverse effect of the released NO on the corrosion behavior of the Mg implant. Simultaneously, the optimal concentration level of NO released from the implant significantly enhances tube network formation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis can be accelerated by combining NO-releasing nanofibers with a Mg implant. With its proven feasibility, the proposed approach could be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fixation. 2020-11-09T20:45:51Z 2020-11-09T20:45:51Z 2019-01 2018-10 2020-09-24T21:50:49Z Article http://purl.org/eprint/type/JournalArticle 1598-9623 2005-4149 https://hdl.handle.net/1721.1/128430 Jeon, Jin-Kyung et al. "Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers." Metals and Materials International 25, 4 (January 2018): 1098–1107 © 2019 The Korean Institute of Metals and Materials en https://doi.org/10.1007/s12540-018-00232-9 Metals and Materials International Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The Korean Institute of Metals and Materials application/pdf Springer Science and Business Media LLC |
| spellingShingle | Jeon, Jin-Kyung Seo, Hyunseon Park, Jimin Son, Soo Ji Kim, Yeong Rim Kim, Eun Shil Park, Jong Woong Jung, Woong-Gyo Jeon, Hojeong Kim, Yu-Chan Seok, Hyun-Kwang Shin, Jae Ho Ok, Myoung-Ryul Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title | Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title_full | Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title_fullStr | Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title_full_unstemmed | Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title_short | Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofibers |
| title_sort | conceptual study for tissue regenerative biodegradable magnesium implant integrated with nitric oxide releasing nanofibers |
| url | https://hdl.handle.net/1721.1/128430 |
| work_keys_str_mv | AT jeonjinkyung conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT seohyunseon conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT parkjimin conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT sonsooji conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT kimyeongrim conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT kimeunshil conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT parkjongwoong conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT jungwoonggyo conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT jeonhojeong conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT kimyuchan conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT seokhyunkwang conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT shinjaeho conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers AT okmyoungryul conceptualstudyfortissueregenerativebiodegradablemagnesiumimplantintegratedwithnitricoxidereleasingnanofibers |