Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to...

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Bibliographic Details
Main Authors: Backman, Lindsey R., Huang, Yolanda Y, Andorfer, Mary, Gold, Brian, Raines, Ronald T, Balskus, Emily P, Drennan, Catherine L
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd 2020
Online Access:https://hdl.handle.net/1721.1/128447

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