Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications
Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when presc...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/128461 |
| _version_ | 1826215913129508864 |
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| author | Reker, Daniel Blum, Steven M. Wade, Peter Steiger, Christoph Winfried Johannes Traverso, Carlo Giovanni |
| author2 | MIT-IBM Watson AI Lab |
| author_facet | MIT-IBM Watson AI Lab Reker, Daniel Blum, Steven M. Wade, Peter Steiger, Christoph Winfried Johannes Traverso, Carlo Giovanni |
| author_sort | Reker, Daniel |
| collection | MIT |
| description | Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when prescribing medications to patients. Methods:
We used data mining to track the number of available formulations for the same medication over time and correlate the number of available versions in 2019 to the number of manufacturers, the years since first approval, and the number of prescriptions. A focused survey among healthcare professionals was conducted to query their consideration of the inactive ingredient portion of a medication when writing prescriptions. Results:
The number of available versions of a single medication have dramatically increased in the last 40 years. The number of available, different versions of medications are largely determined by the number of manufacturers producing this medication. Healthcare providers commonly do not consider the inactive ingredient portion when prescribing a medication. Conclusions: A multitude of available versions of the same medications provides a potentially under-recognized opportunity to prescribe the most suitable formulation to a patient as a step towards personalized medicine and mitigate potential adverse events from inactive ingredients. |
| first_indexed | 2024-09-23T16:39:00Z |
| format | Article |
| id | mit-1721.1/128461 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:39:00Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1284612022-10-03T07:24:26Z Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications Reker, Daniel Blum, Steven M. Wade, Peter Steiger, Christoph Winfried Johannes Traverso, Carlo Giovanni MIT-IBM Watson AI Lab Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Purpose: A multitude of different versions of the same medication with different inactive ingredients are currently available. It has not been quantified how this has evolved historically. Furthermore, it is unknown whether healthcare professionals consider the inactive ingredient portion when prescribing medications to patients. Methods: We used data mining to track the number of available formulations for the same medication over time and correlate the number of available versions in 2019 to the number of manufacturers, the years since first approval, and the number of prescriptions. A focused survey among healthcare professionals was conducted to query their consideration of the inactive ingredient portion of a medication when writing prescriptions. Results: The number of available versions of a single medication have dramatically increased in the last 40 years. The number of available, different versions of medications are largely determined by the number of manufacturers producing this medication. Healthcare providers commonly do not consider the inactive ingredient portion when prescribing a medication. Conclusions: A multitude of available versions of the same medications provides a potentially under-recognized opportunity to prescribe the most suitable formulation to a patient as a step towards personalized medicine and mitigate potential adverse events from inactive ingredients. 2020-11-12T19:28:05Z 2020-11-12T19:28:05Z 2020-10 2020-07 2020-10-30T04:35:34Z Article http://purl.org/eprint/type/JournalArticle 0724-8741 1573-904X https://hdl.handle.net/1721.1/128461 Reker, Daniel et al. "Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications." Pharmaceutical Research 37, 12 (October 2020): 234 © 2020 Springer Science Business Media en http://dx.doi.org/10.1007/s11095-020-02953-2 Pharmaceutical Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer Science and Business Media LLC Springer US |
| spellingShingle | Reker, Daniel Blum, Steven M. Wade, Peter Steiger, Christoph Winfried Johannes Traverso, Carlo Giovanni Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title | Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title_full | Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title_fullStr | Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title_full_unstemmed | Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title_short | Historical Evolution and Provider Awareness of Inactive Ingredients in Oral Medications |
| title_sort | historical evolution and provider awareness of inactive ingredients in oral medications |
| url | https://hdl.handle.net/1721.1/128461 |
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