Polymers for extended-release administration
Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therap...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/128523 |
| _version_ | 1826214322775261184 |
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| author | Paolini, Marion Fenton, Owen Shea Bhattacharya, Chandrabali Andresen, Jason Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Paolini, Marion Fenton, Owen Shea Bhattacharya, Chandrabali Andresen, Jason Langer, Robert S |
| author_sort | Paolini, Marion |
| collection | MIT |
| description | Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with tunable release profiles, and with minimal complication and distress for the patient. To date, drug delivery systems have been developed to serve as depots, triggers, and carriers for therapeutics including small molecules, biologics, and cell-based therapies. Notably, the efficacy of these systems is intricately tied to the manner in which they are administered. For example, systemic and oral routes of administration are common, but both can result in rapid clearance from the organism. Towards this end, what formulation and administration route strategies are available to prolong the bioavailability of therapeutics? Here, we discuss historical and modern drug delivery systems, with the intention of exploring how properties including formulation, administration route and chemical structure influence the ability to achieve extended-release drug release profiles within the body. |
| first_indexed | 2024-09-23T16:03:24Z |
| format | Article |
| id | mit-1721.1/128523 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:03:24Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1285232022-09-29T17:55:37Z Polymers for extended-release administration Paolini, Marion Fenton, Owen Shea Bhattacharya, Chandrabali Andresen, Jason Langer, Robert S Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Developing strategies to deliver the required dose of therapeutics into target tissues and cell populations within the body is a principal aim of controlled release and drug delivery. Specifically, there is an interest in developing formulations that can achieve drug concentrations within the therapeutic window, for extended periods of time, with tunable release profiles, and with minimal complication and distress for the patient. To date, drug delivery systems have been developed to serve as depots, triggers, and carriers for therapeutics including small molecules, biologics, and cell-based therapies. Notably, the efficacy of these systems is intricately tied to the manner in which they are administered. For example, systemic and oral routes of administration are common, but both can result in rapid clearance from the organism. Towards this end, what formulation and administration route strategies are available to prolong the bioavailability of therapeutics? Here, we discuss historical and modern drug delivery systems, with the intention of exploring how properties including formulation, administration route and chemical structure influence the ability to achieve extended-release drug release profiles within the body. 2020-11-18T20:59:21Z 2020-11-18T20:59:21Z 2019-04 2020-09-24T21:37:31Z Article http://purl.org/eprint/type/JournalArticle 1387-2176 1572-8781 https://hdl.handle.net/1721.1/128523 Paolini, Marion S. et al. "Polymers for extended-release administration." Biomedical Microdevices 21, 2 (April 2019): 45 © 2019 Springer Science Business Media, LLC en https://doi.org/10.1007/s10544-019-0386-9 Biomedical Microdevices Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ Springer Science+Business Media, LLC, part of Springer Nature application/pdf Springer Science and Business Media LLC Springer US |
| spellingShingle | Paolini, Marion Fenton, Owen Shea Bhattacharya, Chandrabali Andresen, Jason Langer, Robert S Polymers for extended-release administration |
| title | Polymers for extended-release administration |
| title_full | Polymers for extended-release administration |
| title_fullStr | Polymers for extended-release administration |
| title_full_unstemmed | Polymers for extended-release administration |
| title_short | Polymers for extended-release administration |
| title_sort | polymers for extended release administration |
| url | https://hdl.handle.net/1721.1/128523 |
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