Inflammation-induced DNA damage, mutations and cancer
The relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage. During inflammation reactive oxygen and nitrogen species (RONS) are created to combat pathogens and to stimulate tissue repair and regeneration,...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/128611 |
| _version_ | 1826194107240808448 |
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| author | Kay, Jennifer Elizabeth Thadhani, Elina Samson, Leona D Engelward, Bevin P |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kay, Jennifer Elizabeth Thadhani, Elina Samson, Leona D Engelward, Bevin P |
| author_sort | Kay, Jennifer Elizabeth |
| collection | MIT |
| description | The relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage. During inflammation reactive oxygen and nitrogen species (RONS) are created to combat pathogens and to stimulate tissue repair and regeneration, but these chemicals can also damage DNA, which in turn can promote mutations that initiate and promote cancer. DNA repair pathways are essential for preventing DNA damage from causing mutations and cytotoxicity, but RONS can interfere with repair mechanisms, reducing their efficacy. Further, cellular responses to DNA damage, such as damage signaling and cytotoxicity, can promote inflammation, creating a positive feedback loop. Despite coordination of DNA repair and oxidative stress responses, there are nevertheless examples whereby inflammation has been shown to promote mutagenesis, tissue damage, and ultimately carcinogenesis. Here, we discuss the DNA damage-mediated associations between inflammation, mutagenesis and cancer. |
| first_indexed | 2024-09-23T09:51:05Z |
| format | Article |
| id | mit-1721.1/128611 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:51:05Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1286112022-09-26T14:05:15Z Inflammation-induced DNA damage, mutations and cancer Kay, Jennifer Elizabeth Thadhani, Elina Samson, Leona D Engelward, Bevin P Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology The relationships between inflammation and cancer are varied and complex. An important connection linking inflammation to cancer development is DNA damage. During inflammation reactive oxygen and nitrogen species (RONS) are created to combat pathogens and to stimulate tissue repair and regeneration, but these chemicals can also damage DNA, which in turn can promote mutations that initiate and promote cancer. DNA repair pathways are essential for preventing DNA damage from causing mutations and cytotoxicity, but RONS can interfere with repair mechanisms, reducing their efficacy. Further, cellular responses to DNA damage, such as damage signaling and cytotoxicity, can promote inflammation, creating a positive feedback loop. Despite coordination of DNA repair and oxidative stress responses, there are nevertheless examples whereby inflammation has been shown to promote mutagenesis, tissue damage, and ultimately carcinogenesis. Here, we discuss the DNA damage-mediated associations between inflammation, mutagenesis and cancer. EPA Superfund Research Program (Grant P42ES027707) NIEHS (Grant T32-ES007020) NCI (Grant P01-CA026731) 2020-11-23T21:38:14Z 2020-11-23T21:38:14Z 2019-07 2019-06 2020-11-19T19:53:13Z Article http://purl.org/eprint/type/JournalArticle 1568-7864 https://hdl.handle.net/1721.1/128611 Kay, Jennifer Elizabeth et al. "Inflammation-induced DNA damage, mutations and cancer." DNA Repair 83 (November 2019): 102673 © 2019 Elsevier B.V. en http://dx.doi.org/10.1016/J.DNAREP.2019.102673 DNA Repair Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Kay, Jennifer Elizabeth Thadhani, Elina Samson, Leona D Engelward, Bevin P Inflammation-induced DNA damage, mutations and cancer |
| title | Inflammation-induced DNA damage, mutations and cancer |
| title_full | Inflammation-induced DNA damage, mutations and cancer |
| title_fullStr | Inflammation-induced DNA damage, mutations and cancer |
| title_full_unstemmed | Inflammation-induced DNA damage, mutations and cancer |
| title_short | Inflammation-induced DNA damage, mutations and cancer |
| title_sort | inflammation induced dna damage mutations and cancer |
| url | https://hdl.handle.net/1721.1/128611 |
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