Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2′,2′-difluorodeoxycytidine) into its inactive form, 2′,2′-difluorodeoxyuridine. Metabolism was depend...

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প্রধান লেখক: Geller, Leore T., Barzily-Rokni, Michal, Danino, Tal, Jonas, Oliver H., Shental, Noam, Nejman, Deborah, Gavert, Nancy, Zwang, Yaara, Cooper, Zachary A., Shee, Kevin, Thaiss, Christoph A., Reuben, Alexandre, Livny, Jonathan, Avraham, Roi, Frederick, Dennie T., Ligorio, Matteo, Chatman, Kelly, Johnston, Stephen E., Mosher, Carrie M., Brandis, Alexander, Fuks, Garold, Gurbatri, Candice, Gopalakrishnan, Vancheswaran, Kim, Michael, Hurd, Mark W., Katz, Matthew, Fleming, Jason, Maitra, Anirban, Smith, David A., Skalak, Matthew T., Bu, Jeffrey, Michaud, Monia, Trauger, Sunia A., Barshack, Iris, Golan, Talia, Sandbank, Judith, Flaherty, Keith T., Mandinova, Anna, Garrett, Wendy S., Thayer, Sarah P., Ferrone, Cristina R., Huttenhower, Curtis, Bhatia, Sangeeta N., Gevers, Dirk, Wargo, Jennifer A., Golub, Todd R., Straussman, Ravid
অন্যান্য লেখক: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: American Association for the Advancement of Science (AAAS) 2020
অনলাইন ব্যবহার করুন:https://hdl.handle.net/1721.1/128660

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