Synthetic and living micropropellers for convection-enhanced nanoparticle transport
Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hur...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/128730 |
| _version_ | 1826206949943803904 |
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| author | Schuerle, S Soleimany, Ava Yeh, Tiffany Anand, G. M. Häberli, M Fleming, Heather Mirkhani, N Qiu, F Hauert, S Wang, X Nelson, BJ Bhatia, Saurav |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Schuerle, S Soleimany, Ava Yeh, Tiffany Anand, G. M. Häberli, M Fleming, Heather Mirkhani, N Qiu, F Hauert, S Wang, X Nelson, BJ Bhatia, Saurav |
| author_sort | Schuerle, S |
| collection | MIT |
| description | Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hurdle is transport out of the blood vessels, compounded by difficulties in subsequent penetration into the target tissue. Here, we report the use of two distinct micropropellers powered by rotating magnetic fields to increase diffusion-limited NP transport by enhancing local fluid convection. In the first approach, we used a single synthetic magnetic microrobot called an artificial bacterial flagellum(ABF), and in the second approach,we used swarms of magnetotactic bacteria (MTB) to create a directable "living ferrofluid" by exploiting ferrohydrodynamics. Both approaches enhance NP transport in a microfluidicmodel of blood extravasation and tissue penetration that consists of microchannels bordered by a collagen matrix. |
| first_indexed | 2024-09-23T13:41:26Z |
| format | Article |
| id | mit-1721.1/128730 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:41:26Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1287302022-10-01T16:33:34Z Synthetic and living micropropellers for convection-enhanced nanoparticle transport Schuerle, S Soleimany, Ava Yeh, Tiffany Anand, G. M. Häberli, M Fleming, Heather Mirkhani, N Qiu, F Hauert, S Wang, X Nelson, BJ Bhatia, Saurav Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Koch Institute for Integrative Cancer Research at MIT Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the treatment of various ailments including cancer and cardiovascular and inflammatory diseases. However, their efficacy in shuttling materials to diseased tissue is hampered by a number of physiological barriers. One hurdle is transport out of the blood vessels, compounded by difficulties in subsequent penetration into the target tissue. Here, we report the use of two distinct micropropellers powered by rotating magnetic fields to increase diffusion-limited NP transport by enhancing local fluid convection. In the first approach, we used a single synthetic magnetic microrobot called an artificial bacterial flagellum(ABF), and in the second approach,we used swarms of magnetotactic bacteria (MTB) to create a directable "living ferrofluid" by exploiting ferrohydrodynamics. Both approaches enhance NP transport in a microfluidicmodel of blood extravasation and tissue penetration that consists of microchannels bordered by a collagen matrix. National Cancer Institute (Grant P30-CA1405) 2020-12-04T20:18:08Z 2020-12-04T20:18:08Z 2019-04 2018-09 2020-12-02T17:51:11Z Article http://purl.org/eprint/type/JournalArticle 2375-2548 https://hdl.handle.net/1721.1/128730 Schuerle, S. et al. "Synthetic and living micropropellers for convection-enhanced nanoparticle transport." Science Advances 5, 4 (April 2019): eaav4803 © 2019 The Authors en http://dx.doi.org/10.1126/SCIADV.AAV4803 Science Advances Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf American Association for the Advancement of Science (AAAS) Science Advances |
| spellingShingle | Schuerle, S Soleimany, Ava Yeh, Tiffany Anand, G. M. Häberli, M Fleming, Heather Mirkhani, N Qiu, F Hauert, S Wang, X Nelson, BJ Bhatia, Saurav Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title | Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title_full | Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title_fullStr | Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title_full_unstemmed | Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title_short | Synthetic and living micropropellers for convection-enhanced nanoparticle transport |
| title_sort | synthetic and living micropropellers for convection enhanced nanoparticle transport |
| url | https://hdl.handle.net/1721.1/128730 |
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