Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system
Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of b...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2020
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| Online Access: | https://hdl.handle.net/1721.1/128874 |
| _version_ | 1826205821271277568 |
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| author | Peng, Weng Kung Chen, Lan Boehm, Bernhard O. Han, Jongyoon Loh, Tze Ping |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Peng, Weng Kung Chen, Lan Boehm, Bernhard O. Han, Jongyoon Loh, Tze Ping |
| author_sort | Peng, Weng Kung |
| collection | MIT |
| description | Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T1–T2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management. |
| first_indexed | 2024-09-23T13:19:57Z |
| format | Article |
| id | mit-1721.1/128874 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:19:57Z |
| publishDate | 2020 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1288742022-10-01T14:35:03Z Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system Peng, Weng Kung Chen, Lan Boehm, Bernhard O. Han, Jongyoon Loh, Tze Ping Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Biological Engineering Diabetes mellitus is one of the fastest-growing health burdens globally. Oxidative stress, which has been implicated in the pathogenesis of diabetes complication (e.g., cardiovascular event), remains poorly understood. We report a new approach to rapidly manipulate and evaluate the redox states of blood using a point-of-care NMR system. Various redox states of the hemoglobin were mapped out using the newly proposed (pseudo) two-dimensional map known as T1–T2 magnetic state diagram. We exploit the fact that oxidative stress changes the subtle molecular motion of water proton in the blood, and thus inducing a measurable shift in magnetic resonance relaxation properties. We demonstrated the clinical utilities of this technique to rapidly stratify diabetes subjects based on their oxidative status in conjunction to the traditional glycemic level to improve the patient stratification and thus the overall outcome of clinical diabetes care and management. 2020-12-21T16:49:16Z 2020-12-21T16:49:16Z 2020-10 2020-05 2020-12-17T13:57:38Z Article http://purl.org/eprint/type/JournalArticle 2056-3973 https://hdl.handle.net/1721.1/128874 Peng, Weng Kung et al. "Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system." npj Aging and Mechanisms of Disease 6, 1 (October 2020): 11 © 2020 The Author(s) en http://dx.doi.org/10.1038/s41514-020-00049-0 npj Aging and Mechanisms of Disease Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Nature |
| spellingShingle | Peng, Weng Kung Chen, Lan Boehm, Bernhard O. Han, Jongyoon Loh, Tze Ping Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title | Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title_full | Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title_fullStr | Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title_full_unstemmed | Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title_short | Molecular phenotyping of oxidative stress in diabetes mellitus with point-of-care NMR system |
| title_sort | molecular phenotyping of oxidative stress in diabetes mellitus with point of care nmr system |
| url | https://hdl.handle.net/1721.1/128874 |
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