Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise
Artificial gravity (AG) has often been proposed as an integrated multisystem countermeasure to physiological deconditioning associated with extended exposure to reduced gravity levels, particularly if combined with exercise. Twelve subjects underwent short-radius centrifugation along with bicycle er...
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Frontiers Media SA
2020
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| Sarrera elektronikoa: | https://hdl.handle.net/1721.1/128898 |
| _version_ | 1826214668048269312 |
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| author | Diaz-Artiles, Ana Heldt, Thomas Young, Laurence Retman |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Diaz-Artiles, Ana Heldt, Thomas Young, Laurence Retman |
| author_sort | Diaz-Artiles, Ana |
| collection | MIT |
| description | Artificial gravity (AG) has often been proposed as an integrated multisystem countermeasure to physiological deconditioning associated with extended exposure to reduced gravity levels, particularly if combined with exercise. Twelve subjects underwent short-radius centrifugation along with bicycle ergometry to quantify the short-term cardiovascular response to AG and exercise across three AG levels (0 G or no rotation, 1 G, and 1.4 G; referenced to the subject's feet and measured in the centripetal direction) and three exercise intensities (25, 50, and 100 W). Continuous cardiovascular measurements were collected during the centrifugation sessions using a non-invasive monitoring system. The cardiovascular responses were more prominent at higher levels of AG and exercise intensity. In particular, cardiac output, stroke volume, pulse pressure, and heart rate significantly increased with both AG level (in most of exercise group combinations, showing averaged increments across exercise conditions of 1.4 L/min/g, 7.6 mL/g, 5.22 mmHg/g, and 2.0 bpm/g, respectively), and workload intensity (averaged increments across AG conditions of 0.09 L/min/W, 0.17 mL/W, 0.22 mmHg/W, and 0.74 bpm/W respectively). These results suggest that the addition of AG to exercise can provide a greater cardiovascular benefit than exercise alone. Hierarchical regression models were fitted to the experimental data to determine dose-response curves of all cardiovascular variables as a function of AG-level and exercise intensity during short-radius centrifugation. These results can inform future studies, decisions, and trade-offs toward potential implementation of AG as a space countermeasure. |
| first_indexed | 2024-09-23T16:09:06Z |
| format | Article |
| id | mit-1721.1/128898 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:09:06Z |
| publishDate | 2020 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | mit-1721.1/1288982022-10-02T06:42:49Z Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise Diaz-Artiles, Ana Heldt, Thomas Young, Laurence Retman Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Department of Aeronautics and Astronautics Artificial gravity (AG) has often been proposed as an integrated multisystem countermeasure to physiological deconditioning associated with extended exposure to reduced gravity levels, particularly if combined with exercise. Twelve subjects underwent short-radius centrifugation along with bicycle ergometry to quantify the short-term cardiovascular response to AG and exercise across three AG levels (0 G or no rotation, 1 G, and 1.4 G; referenced to the subject's feet and measured in the centripetal direction) and three exercise intensities (25, 50, and 100 W). Continuous cardiovascular measurements were collected during the centrifugation sessions using a non-invasive monitoring system. The cardiovascular responses were more prominent at higher levels of AG and exercise intensity. In particular, cardiac output, stroke volume, pulse pressure, and heart rate significantly increased with both AG level (in most of exercise group combinations, showing averaged increments across exercise conditions of 1.4 L/min/g, 7.6 mL/g, 5.22 mmHg/g, and 2.0 bpm/g, respectively), and workload intensity (averaged increments across AG conditions of 0.09 L/min/W, 0.17 mL/W, 0.22 mmHg/W, and 0.74 bpm/W respectively). These results suggest that the addition of AG to exercise can provide a greater cardiovascular benefit than exercise alone. Hierarchical regression models were fitted to the experimental data to determine dose-response curves of all cardiovascular variables as a function of AG-level and exercise intensity during short-radius centrifugation. These results can inform future studies, decisions, and trade-offs toward potential implementation of AG as a space countermeasure. MIT/Skolkovo (Grant 6925991) 2020-12-22T20:28:49Z 2020-12-22T20:28:49Z 2018-11 2018-07 2019-05-30T19:34:22Z Article http://purl.org/eprint/type/JournalArticle 1664-042X https://hdl.handle.net/1721.1/128898 Diaz-Artiles, Ana et al. "Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise." Frontiers in Physiology 9 (November 2018): 1492 © 2018 Diaz-Artiles en http://dx.doi.org/10.3389/fphys.2018.01492 Frontiers in Physiology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Frontiers Media SA Frontiers |
| spellingShingle | Diaz-Artiles, Ana Heldt, Thomas Young, Laurence Retman Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title | Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title_full | Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title_fullStr | Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title_full_unstemmed | Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title_short | Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise |
| title_sort | short term cardiovascular response to short radius centrifugation with and without ergometer exercise |
| url | https://hdl.handle.net/1721.1/128898 |
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