Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography
PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. METHODS: In this retrospective, cross-sectional study,...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Association for Research in Vision and Ophthalmology (ARVO)
2021
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| Online Access: | https://hdl.handle.net/1721.1/128928 |
| _version_ | 1811095922261622784 |
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| author | Braun, Phillip X. Mehta, Nihaal Gendelman, Isaac Alibhai, A. Yasin Moult, Eric Michael Zhao, Yi Ishibazawa, Akihiro Sorour, Osama Konstantinou, Eleni K. Baumal, Caroline R. Witkin, Andre J. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Braun, Phillip X. Mehta, Nihaal Gendelman, Isaac Alibhai, A. Yasin Moult, Eric Michael Zhao, Yi Ishibazawa, Akihiro Sorour, Osama Konstantinou, Eleni K. Baumal, Caroline R. Witkin, Andre J. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. |
| author_sort | Braun, Phillip X. |
| collection | MIT |
| description | PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. METHODS: In this retrospective, cross-sectional study, 6 3 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and average flow deficit size. Regions were defined by concentric areas centered on the fovea: a 1-mm-diameter area, 3-mm-diameter ring, 5-mm-diameter area, 5-mm-diameter ring, and 6 3 6-mm whole image. Data were modeled using the generalized estimating equations approach. RESULTS: The relationship between age and CC FD% and average flow deficit size was statistically significant (P ≼ 0.05) in all regions of analysis by linear modeling. The relationship between dry AMD stage and FD% was statistically significant by linear modeling in the 5-mm ring, and between dry AMD stage and average flow deficit size in the 3-mm ring, 5-mm area, 5-mm ring, and 6 3 6-mm whole image. CONCLUSIONS. Linear modeling suggests a statistically significant relationship between dry AMD stage and CC perfusion, most prominent in the more peripheral regions of the macula. |
| first_indexed | 2024-09-23T16:34:16Z |
| format | Article |
| id | mit-1721.1/128928 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:34:16Z |
| publishDate | 2021 |
| publisher | Association for Research in Vision and Ophthalmology (ARVO) |
| record_format | dspace |
| spelling | mit-1721.1/1289282022-10-02T08:19:14Z Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography Braun, Phillip X. Mehta, Nihaal Gendelman, Isaac Alibhai, A. Yasin Moult, Eric Michael Zhao, Yi Ishibazawa, Akihiro Sorour, Osama Konstantinou, Eleni K. Baumal, Caroline R. Witkin, Andre J. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Institute for Medical Engineering & Science PURPOSE: Swept-source optical coherence tomography angiography (SS-OCTA) was used to investigate if the clinical stage of dry age-related macular degeneration (AMD) was correlated with global and regional macular choriocapillaris (CC) perfusion. METHODS: In this retrospective, cross-sectional study, 6 3 6-mm SS-OCTA images from eyes with early, intermediate, and advanced dry AMD (56 eyes, 41 patients) were analyzed using algorithms described in the literature to assess regional flow deficit percentage (FD%) and average flow deficit size. Regions were defined by concentric areas centered on the fovea: a 1-mm-diameter area, 3-mm-diameter ring, 5-mm-diameter area, 5-mm-diameter ring, and 6 3 6-mm whole image. Data were modeled using the generalized estimating equations approach. RESULTS: The relationship between age and CC FD% and average flow deficit size was statistically significant (P ≼ 0.05) in all regions of analysis by linear modeling. The relationship between dry AMD stage and FD% was statistically significant by linear modeling in the 5-mm ring, and between dry AMD stage and average flow deficit size in the 3-mm ring, 5-mm area, 5-mm ring, and 6 3 6-mm whole image. CONCLUSIONS. Linear modeling suggests a statistically significant relationship between dry AMD stage and CC perfusion, most prominent in the more peripheral regions of the macula. National Institutes of Health (Grant 5-R01- EY011289-31) Air Force Office of Scientific Research (Grant FA9550-15-1-0473) National Institute of Diabetes and Digestive and Kidney Diseases Medical Student Research Fellowship (Award T35DK104689) National Center for Advancing Translational Sciences (Award TL1-TR001864) 2021-01-04T16:53:40Z 2021-01-04T16:53:40Z 2019-12 2019-06 2020-12-14T20:08:44Z Article http://purl.org/eprint/type/JournalArticle 1552-5783 https://hdl.handle.net/1721.1/128928 Braun, Phillip X. et al. "Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography." Investigative Ophthalmology and Visual Science 60, 15 (December 2019): 4985–4990. © 2019 The Authors en http://dx.doi.org/10.1167/iovs.19-27861 Investigative Ophthalmology and Visual Science Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Association for Research in Vision and Ophthalmology (ARVO) Investigative Ophthalmology & Visual Science |
| spellingShingle | Braun, Phillip X. Mehta, Nihaal Gendelman, Isaac Alibhai, A. Yasin Moult, Eric Michael Zhao, Yi Ishibazawa, Akihiro Sorour, Osama Konstantinou, Eleni K. Baumal, Caroline R. Witkin, Andre J. Fujimoto, James G Duker, Jay S. Waheed, Nadia K. Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title | Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title_full | Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title_fullStr | Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title_full_unstemmed | Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title_short | Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography |
| title_sort | global analysis of macular choriocapillaris perfusion in dry age related macular degeneration using swept source optical coherence tomography angiography |
| url | https://hdl.handle.net/1721.1/128928 |
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