Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. The...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
MDPI AG
2021
|
| Online Access: | https://hdl.handle.net/1721.1/128956 |
| _version_ | 1826204648322629632 |
|---|---|
| author | Concellon Allueva, Alberto San Anselmo, María Hernández-Ainsa, Silvia Romero, Pilar Marcos, Mercedes Serrano, José Luis |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Concellon Allueva, Alberto San Anselmo, María Hernández-Ainsa, Silvia Romero, Pilar Marcos, Mercedes Serrano, José Luis |
| author_sort | Concellon Allueva, Alberto |
| collection | MIT |
| description | The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. |
| first_indexed | 2024-09-23T12:58:47Z |
| format | Article |
| id | mit-1721.1/128956 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:58:47Z |
| publishDate | 2021 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/1289562022-10-01T12:18:40Z Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties Concellon Allueva, Alberto San Anselmo, María Hernández-Ainsa, Silvia Romero, Pilar Marcos, Mercedes Serrano, José Luis Massachusetts Institute of Technology. Department of Chemistry The design of efficient drug-delivery vehicles remains a big challenge in materials science. Herein, we describe a novel class of amphiphilic hybrid dendrimers that consist of a poly(amidoamine) (PAMAM) dendritic core functionalized with bisMPA dendrons bearing cholesterol and coumarin moieties. Their self-assembly behavior both in bulk and in water was investigated. All dendrimers exhibited smectic A or hexagonal columnar liquid crystal organizations, depending on the generation of the dendrimer. In water, these dendrimers self-assembled to form stable spherical micelles that could encapsulate Nile Red, a hydrophobic model compound. The cell viability in vitro of the micelles was studied in HeLa cell line, and proved to be non-toxic up to 72 h of incubation. Therefore, these spherical micelles allow the encapsulation of hydrophobic molecules, and at the same time provided fluorescent traceability due to the presence of coumarin units in their chemical structure, demonstrating the potential of these dendrimers as nanocarriers for drug-delivery applications. 2021-01-05T19:56:06Z 2021-01-05T19:56:06Z 2020-11 2020-11 2020-12-10T14:11:11Z Article http://purl.org/eprint/type/JournalArticle 2073-4360 https://hdl.handle.net/1721.1/128956 Concellón, Alberto et al. "Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties." Polymers 12, 12 (November 2020): 2872 © 2020 The Authors http://dx.doi.org/10.3390/polym12122872 Polymers Creative Commons Attribution https://creativecommons.org/licenses/by/4.0/ application/pdf MDPI AG Multidisciplinary Digital Publishing Institute |
| spellingShingle | Concellon Allueva, Alberto San Anselmo, María Hernández-Ainsa, Silvia Romero, Pilar Marcos, Mercedes Serrano, José Luis Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title | Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title_full | Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title_fullStr | Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title_full_unstemmed | Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title_short | Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties |
| title_sort | micellar nanocarriers from dendritic macromolecules containing fluorescent coumarin moieties |
| url | https://hdl.handle.net/1721.1/128956 |
| work_keys_str_mv | AT concellonalluevaalberto micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties AT sananselmomaria micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties AT hernandezainsasilvia micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties AT romeropilar micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties AT marcosmercedes micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties AT serranojoseluis micellarnanocarriersfromdendriticmacromoleculescontainingfluorescentcoumarinmoieties |