MicroRNA delivery through nanoparticles
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This revi...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/129476 |
| _version_ | 1811071040954040320 |
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| author | Lee, Sharon Wei Ling Paoletti, Camilla Campisi, Marco Osaki, Tatsuya Adriani, Giulia Kamm, Roger Dale Mattu, Clara Chiono, Valeria |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Lee, Sharon Wei Ling Paoletti, Camilla Campisi, Marco Osaki, Tatsuya Adriani, Giulia Kamm, Roger Dale Mattu, Clara Chiono, Valeria |
| author_sort | Lee, Sharon Wei Ling |
| collection | MIT |
| description | MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine. |
| first_indexed | 2024-09-23T08:45:12Z |
| format | Article |
| id | mit-1721.1/129476 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:45:12Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1294762022-09-23T14:19:24Z MicroRNA delivery through nanoparticles Lee, Sharon Wei Ling Paoletti, Camilla Campisi, Marco Osaki, Tatsuya Adriani, Giulia Kamm, Roger Dale Mattu, Clara Chiono, Valeria Massachusetts Institute of Technology. Department of Mechanical Engineering Massachusetts Institute of Technology. Department of Biological Engineering MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine. National Science Foundation (Grant CBET-0939511) National Cancer Institute (Grant U01-CA214381-01) 2021-01-20T18:56:01Z 2021-01-20T18:56:01Z 2019-11 2019-10 2020-08-17T17:02:19Z Article http://purl.org/eprint/type/JournalArticle 0168-3659 https://hdl.handle.net/1721.1/129476 Lee, Sharon Wei Ling et al. "MicroRNA delivery through nanoparticles." Journal of Controlled Release 313 (November 2019): 80-95 © 2019 The Authors en http://dx.doi.org/10.1016/j.jconrel.2019.10.007 Journal of Controlled Release Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Lee, Sharon Wei Ling Paoletti, Camilla Campisi, Marco Osaki, Tatsuya Adriani, Giulia Kamm, Roger Dale Mattu, Clara Chiono, Valeria MicroRNA delivery through nanoparticles |
| title | MicroRNA delivery through nanoparticles |
| title_full | MicroRNA delivery through nanoparticles |
| title_fullStr | MicroRNA delivery through nanoparticles |
| title_full_unstemmed | MicroRNA delivery through nanoparticles |
| title_short | MicroRNA delivery through nanoparticles |
| title_sort | microrna delivery through nanoparticles |
| url | https://hdl.handle.net/1721.1/129476 |
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