Developing a potential retinal OCT biomarker for local growth of geographic atrophy
Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-base...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
The Optical Society
2021
|
| Online Access: | https://hdl.handle.net/1721.1/129545 |
| _version_ | 1826200077884981248 |
|---|---|
| author | Yu, Yue Moult, Eric Michael Chen, Siyu Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Yu, Yue Moult, Eric Michael Chen, Siyu Fujimoto, James G |
| author_sort | Yu, Yue |
| collection | MIT |
| description | Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies. |
| first_indexed | 2024-09-23T11:30:50Z |
| format | Article |
| id | mit-1721.1/129545 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:30:50Z |
| publishDate | 2021 |
| publisher | The Optical Society |
| record_format | dspace |
| spelling | mit-1721.1/1295452022-10-01T04:06:27Z Developing a potential retinal OCT biomarker for local growth of geographic atrophy Yu, Yue Moult, Eric Michael Chen, Siyu Fujimoto, James G Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Research Laboratory of Electronics Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Geographic atrophy (GA), the advanced stage of age-related macular degeneration, is a leading cause of blindness. GA lesions are characterized by anisotropic growth and the ability to predict growth patterns would be valuable in assessing potential therapeutics. In this study, we propose an OCT-based marker of local GA growth rate based on an axial projection of the OCT volume in the Henle fiber layer (HFL) and outer nuclear layer (ONL). We analyze the association between our proposed metric and local GA growth rates in a small longitudinal cohort of patients with AMD. These methods can potentially be used to identify risk markers, stratify patients, or assess response in future therapeutic studies. China Scholarship Council (201806010297) National Institutes of Health (U.S.) (Grant 5-R01-EY011289-31) 2021-01-25T16:58:31Z 2021-01-25T16:58:31Z 2020-09 2020-07 2020-12-15T13:40:06Z Article http://purl.org/eprint/type/JournalArticle 2156-7085 https://hdl.handle.net/1721.1/129545 Yu, Yue et al. “Developing a potential retinal OCT biomarker for local growth of geographic atrophy.” Biomedical Optics Express, 11, 9 (September 2020): 399506 © 2020 The Author(s) en 10.1364/BOE.399506 Biomedical Optics Express Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf The Optical Society OSA Publishing |
| spellingShingle | Yu, Yue Moult, Eric Michael Chen, Siyu Fujimoto, James G Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title | Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title_full | Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title_fullStr | Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title_full_unstemmed | Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title_short | Developing a potential retinal OCT biomarker for local growth of geographic atrophy |
| title_sort | developing a potential retinal oct biomarker for local growth of geographic atrophy |
| url | https://hdl.handle.net/1721.1/129545 |
| work_keys_str_mv | AT yuyue developingapotentialretinaloctbiomarkerforlocalgrowthofgeographicatrophy AT moultericmichael developingapotentialretinaloctbiomarkerforlocalgrowthofgeographicatrophy AT chensiyu developingapotentialretinaloctbiomarkerforlocalgrowthofgeographicatrophy AT fujimotojamesg developingapotentialretinaloctbiomarkerforlocalgrowthofgeographicatrophy |