Distributed changes of the functional connectome in patients with glioblastoma
Glioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this inte...
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| Format: | Article |
| Language: | English |
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Springer Science and Business Media LLC
2021
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| Online Access: | https://hdl.handle.net/1721.1/129546 |
| _version_ | 1811091071178899456 |
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| author | Golland, Polina Langs, Georg |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Golland, Polina Langs, Georg |
| author_sort | Golland, Polina |
| collection | MIT |
| description | Glioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this interrelation is limited. In this study, we used resting-state functional magnetic resonance imaging to evaluate changes in global functional connectivity patterns in 15 patients with glioblastoma. For six patients we followed longitudinal trajectories of their functional connectome and structural tumour evolution using bi-monthly follow-up scans throughout treatment and disease progression. In all patients, unilateral tumour lesions were associated with inter-hemispherically symmetric network alterations, and functional proximity of tumour location was stronger linked to distributed network deterioration than anatomical distance. In the longitudinal subcohort of six patients, we observed patterns of network alterations with initial transient deterioration followed by recovery at first follow-up, and local network deterioration to precede structural tumour recurrence by two months. In summary, the impact of focal glioblastoma lesions on the functional connectome is global and linked to functional proximity rather than anatomical distance to tumour regions. Our findings further suggest a relevance for functional network trajectories as a possible means supporting early detection of tumour recurrence. |
| first_indexed | 2024-09-23T14:56:34Z |
| format | Article |
| id | mit-1721.1/129546 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:56:34Z |
| publishDate | 2021 |
| publisher | Springer Science and Business Media LLC |
| record_format | dspace |
| spelling | mit-1721.1/1295462022-09-29T11:35:04Z Distributed changes of the functional connectome in patients with glioblastoma Golland, Polina Langs, Georg Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Glioblastoma might have widespread effects on the neural organization and cognitive function, and even focal lesions may be associated with distributed functional alterations. However, functional changes do not necessarily follow obvious anatomical patterns and the current understanding of this interrelation is limited. In this study, we used resting-state functional magnetic resonance imaging to evaluate changes in global functional connectivity patterns in 15 patients with glioblastoma. For six patients we followed longitudinal trajectories of their functional connectome and structural tumour evolution using bi-monthly follow-up scans throughout treatment and disease progression. In all patients, unilateral tumour lesions were associated with inter-hemispherically symmetric network alterations, and functional proximity of tumour location was stronger linked to distributed network deterioration than anatomical distance. In the longitudinal subcohort of six patients, we observed patterns of network alterations with initial transient deterioration followed by recovery at first follow-up, and local network deterioration to precede structural tumour recurrence by two months. In summary, the impact of focal glioblastoma lesions on the functional connectome is global and linked to functional proximity rather than anatomical distance to tumour regions. Our findings further suggest a relevance for functional network trajectories as a possible means supporting early detection of tumour recurrence. Austrian Science Fund (Grants WF KLI394, FWF I2714-B31, FWF I3925–B27) European Union. Horizon 2020 Research and Innovation Programme (Grant 765148 TRABIT) National Institutes of Health (U.S.) (Grants Grants NIBIB NAC P41EB015902, NICHD U01HD087211, NIH NINDS U19NS115388, NIH NICHD R01HD100009) 2021-01-25T17:23:13Z 2021-01-25T17:23:13Z 2020-10 2020-12-16T17:36:32Z Article http://purl.org/eprint/type/JournalArticle 0169-5487 https://hdl.handle.net/1721.1/129546 Nenning, Karl‑Heinz et al. “Distributed changes of the functional connectome in patients with glioblastoma.” Scientific Reports, 10, 1 (October 2020): 18312 © 2020 The Author(s) en 10.1038/s41598-020-74726-1 Scientific Reports Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Science and Business Media LLC Scientific Reports |
| spellingShingle | Golland, Polina Langs, Georg Distributed changes of the functional connectome in patients with glioblastoma |
| title | Distributed changes of the functional connectome in patients with glioblastoma |
| title_full | Distributed changes of the functional connectome in patients with glioblastoma |
| title_fullStr | Distributed changes of the functional connectome in patients with glioblastoma |
| title_full_unstemmed | Distributed changes of the functional connectome in patients with glioblastoma |
| title_short | Distributed changes of the functional connectome in patients with glioblastoma |
| title_sort | distributed changes of the functional connectome in patients with glioblastoma |
| url | https://hdl.handle.net/1721.1/129546 |
| work_keys_str_mv | AT gollandpolina distributedchangesofthefunctionalconnectomeinpatientswithglioblastoma AT langsgeorg distributedchangesofthefunctionalconnectomeinpatientswithglioblastoma |