Placental MRI: Developing Accurate Quantitative Measures of Oxygenation
The Human Placenta Project has focused attention on the need for noninvasive magnetic resonance imaging (MRI)-based techniques to diagnose and monitor placental function throughout pregnancy. The hope is that the management of placenta-related pathologies would be improved if physicians had more dir...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Ovid Technologies (Wolters Kluwer Health)
2021
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| Online Access: | https://hdl.handle.net/1721.1/129563 |
| _version_ | 1826216144835444736 |
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| author | Abaci Turk, Esra Stout, Jeffrey N. Ha, Christopher Luo, Jie Gagoski, Borjan Yetisir, Filiz Golland, Polina Wald, Lawrence L. Adalsteinsson, Elfar Robinson, Julian N. Roberts, Drucilla J. Barth, William H. Grant, P. Ellen |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Abaci Turk, Esra Stout, Jeffrey N. Ha, Christopher Luo, Jie Gagoski, Borjan Yetisir, Filiz Golland, Polina Wald, Lawrence L. Adalsteinsson, Elfar Robinson, Julian N. Roberts, Drucilla J. Barth, William H. Grant, P. Ellen |
| author_sort | Abaci Turk, Esra |
| collection | MIT |
| description | The Human Placenta Project has focused attention on the need for noninvasive magnetic resonance imaging (MRI)-based techniques to diagnose and monitor placental function throughout pregnancy. The hope is that the management of placenta-related pathologies would be improved if physicians had more direct, real-time measures of placental health to guide clinical decision making. As oxygen alters signal intensity on MRI and oxygen transport is a key function of the placenta, many of the MRI methods under development are focused on quantifying oxygen transport or oxygen content of the placenta. For example, measurements from blood oxygen level-dependent imaging of the placenta during maternal hyperoxia correspond to outcomes in twin pregnancies, suggesting that some aspects of placental oxygen transport can be monitored by MRI. Additional methods are being developed to accurately quantify baseline placental oxygenation by MRI relaxometry. However, direct validation of placental MRI methods is challenging and therefore animal studies and ex vivo studies of human placentas are needed. Here we provide an overview of the current state of the art of oxygen transport and quantification with MRI. We suggest that as these techniques are being developed, increased focus be placed on ensuring they are robust and reliable across individuals and standardized to enable predictive diagnostic models to be generated from the data. The field is still several years away from establishing the clinical benefit of monitoring placental function in real time with MRI, but the promise of individual personalized diagnosis and monitoring of placental disease in real time continues to motivate this effort. |
| first_indexed | 2024-09-23T16:42:39Z |
| format | Article |
| id | mit-1721.1/129563 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:42:39Z |
| publishDate | 2021 |
| publisher | Ovid Technologies (Wolters Kluwer Health) |
| record_format | dspace |
| spelling | mit-1721.1/1295632022-09-29T20:59:47Z Placental MRI: Developing Accurate Quantitative Measures of Oxygenation Developing Accurate Quantitative Measures of Oxygenation Abaci Turk, Esra Stout, Jeffrey N. Ha, Christopher Luo, Jie Gagoski, Borjan Yetisir, Filiz Golland, Polina Wald, Lawrence L. Adalsteinsson, Elfar Robinson, Julian N. Roberts, Drucilla J. Barth, William H. Grant, P. Ellen Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology The Human Placenta Project has focused attention on the need for noninvasive magnetic resonance imaging (MRI)-based techniques to diagnose and monitor placental function throughout pregnancy. The hope is that the management of placenta-related pathologies would be improved if physicians had more direct, real-time measures of placental health to guide clinical decision making. As oxygen alters signal intensity on MRI and oxygen transport is a key function of the placenta, many of the MRI methods under development are focused on quantifying oxygen transport or oxygen content of the placenta. For example, measurements from blood oxygen level-dependent imaging of the placenta during maternal hyperoxia correspond to outcomes in twin pregnancies, suggesting that some aspects of placental oxygen transport can be monitored by MRI. Additional methods are being developed to accurately quantify baseline placental oxygenation by MRI relaxometry. However, direct validation of placental MRI methods is challenging and therefore animal studies and ex vivo studies of human placentas are needed. Here we provide an overview of the current state of the art of oxygen transport and quantification with MRI. We suggest that as these techniques are being developed, increased focus be placed on ensuring they are robust and reliable across individuals and standardized to enable predictive diagnostic models to be generated from the data. The field is still several years away from establishing the clinical benefit of monitoring placental function in real time with MRI, but the promise of individual personalized diagnosis and monitoring of placental disease in real time continues to motivate this effort. National Institutes of Health (Grants NICHD U01HD087211, NIBIB R01EB01733) 2021-01-26T15:02:08Z 2021-01-26T15:02:08Z 2019-10 2020-11-20T17:40:33Z Article http://purl.org/eprint/type/JournalArticle 0899-3459 https://hdl.handle.net/1721.1/129563 Abaci Turk, Esra et al. "Developing Accurate Quantitative Measures of Oxygenation." Topics in Magnetic Resonance Imaging 28, 5 (October 2019): 285-297. © 2019 Wolters Kluwer Health, Inc. en http://dx.doi.org/10.1097/rmr.0000000000000221 Topics in Magnetic Resonance Imaging Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Ovid Technologies (Wolters Kluwer Health) PMC |
| spellingShingle | Abaci Turk, Esra Stout, Jeffrey N. Ha, Christopher Luo, Jie Gagoski, Borjan Yetisir, Filiz Golland, Polina Wald, Lawrence L. Adalsteinsson, Elfar Robinson, Julian N. Roberts, Drucilla J. Barth, William H. Grant, P. Ellen Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title | Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title_full | Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title_fullStr | Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title_full_unstemmed | Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title_short | Placental MRI: Developing Accurate Quantitative Measures of Oxygenation |
| title_sort | placental mri developing accurate quantitative measures of oxygenation |
| url | https://hdl.handle.net/1721.1/129563 |
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