Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19
We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier BV
2021
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| Online Access: | https://hdl.handle.net/1721.1/129607 |
| _version_ | 1826208879946498048 |
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| author | Conklin, John Frosch, Matthew Mukerji, Shibani S. Rapalino, Otto Maher, Mary D. Schaefer, Pamela W. Lev, Michael H. Gonzalez, R.G. Das, Sudeshna Champion, Samantha N. Magdamo, Colin Sen, Pritha Harrold, G. Kyle Alabsi, Haitham Normandin, Erica Shaw, Bennett Lemieux, Jacob E. Sabeti, Pardis Branda, John A. Brown, Emery Neal Westover, M Brandon Huang, Susie Y. Edlow, Brian L. |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Conklin, John Frosch, Matthew Mukerji, Shibani S. Rapalino, Otto Maher, Mary D. Schaefer, Pamela W. Lev, Michael H. Gonzalez, R.G. Das, Sudeshna Champion, Samantha N. Magdamo, Colin Sen, Pritha Harrold, G. Kyle Alabsi, Haitham Normandin, Erica Shaw, Bennett Lemieux, Jacob E. Sabeti, Pardis Branda, John A. Brown, Emery Neal Westover, M Brandon Huang, Susie Y. Edlow, Brian L. |
| author_sort | Conklin, John |
| collection | MIT |
| description | We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter. |
| first_indexed | 2024-09-23T14:13:46Z |
| format | Article |
| id | mit-1721.1/129607 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T14:13:46Z |
| publishDate | 2021 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1296072022-09-28T19:22:49Z Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 Conklin, John Frosch, Matthew Mukerji, Shibani S. Rapalino, Otto Maher, Mary D. Schaefer, Pamela W. Lev, Michael H. Gonzalez, R.G. Das, Sudeshna Champion, Samantha N. Magdamo, Colin Sen, Pritha Harrold, G. Kyle Alabsi, Haitham Normandin, Erica Shaw, Bennett Lemieux, Jacob E. Sabeti, Pardis Branda, John A. Brown, Emery Neal Westover, M Brandon Huang, Susie Y. Edlow, Brian L. Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identified. Eleven patients had punctate susceptibility-weighted imaging (SWI) lesions in the subcortical and deep white matter, eight patients had >10 SWI lesions, and four patients had lesions involving the corpus callosum. The distribution of SWI lesions was similar to that seen in patients with hypoxic respiratory failure, sepsis, and disseminated intravascular coagulation. Brain autopsy in one patient revealed that SWI lesions corresponded to widespread microvascular injury, characterized by perivascular and parenchymal petechial hemorrhages and microscopic ischemic lesions. Collectively, these radiologic and histopathologic findings add to growing evidence that patients with severe COVID-19 are at risk for multifocal microvascular hemorrhagic and ischemic lesions in the subcortical and deep white matter. National Institute of Neurological Disorders and Stroke (Grants R21NS109627, R21AG067562, RF1NS115268) NIH Director’s Office (Grant DP2HD101400) NIH National Institute of Mental Health (Grant K23MH115812) NIH National Institutes of Allergy and Infectious Diseases (Grant 2U19AI110818) 2021-02-01T16:31:40Z 2021-02-01T16:31:40Z 2021-02 2020-12 Article http://purl.org/eprint/type/JournalArticle 0022-510X https://hdl.handle.net/1721.1/129607 Conklin, John et al. "Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19." Journal of the Neurological Sciences 421 (February 2021): 117308 © 2021 The Author(s) https://doi.org/10.1016/j.jns.2021.117308 Journal of the Neurological Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Conklin, John Frosch, Matthew Mukerji, Shibani S. Rapalino, Otto Maher, Mary D. Schaefer, Pamela W. Lev, Michael H. Gonzalez, R.G. Das, Sudeshna Champion, Samantha N. Magdamo, Colin Sen, Pritha Harrold, G. Kyle Alabsi, Haitham Normandin, Erica Shaw, Bennett Lemieux, Jacob E. Sabeti, Pardis Branda, John A. Brown, Emery Neal Westover, M Brandon Huang, Susie Y. Edlow, Brian L. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title | Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title_full | Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title_fullStr | Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title_full_unstemmed | Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title_short | Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 |
| title_sort | susceptibility weighted imaging reveals cerebral microvascular injury in severe covid 19 |
| url | https://hdl.handle.net/1721.1/129607 |
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