Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment
Background: A digital version of the clock drawing test (dCDT) provides new latency and graphomotor behavioral measurements. These variables have yet to be validated with external neuropsychological domains in non-demented adults. Objective: The current investigation reports on cognitive constructs...
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artikel |
| Språk: | English |
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IOS Press
2021
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| Länkar: | https://hdl.handle.net/1721.1/129815 |
| _version_ | 1826214103126900736 |
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| author | Dion, Catherine Arias, Franchesca Amini, Shawna Davis, Randall Penney, Dana Libon, David J. Price, Catherine C. |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Dion, Catherine Arias, Franchesca Amini, Shawna Davis, Randall Penney, Dana Libon, David J. Price, Catherine C. |
| author_sort | Dion, Catherine |
| collection | MIT |
| description | Background: A digital version of the clock drawing test (dCDT) provides new latency and graphomotor behavioral measurements. These variables have yet to be validated with external neuropsychological domains in non-demented adults. Objective: The current investigation reports on cognitive constructs associated with selected dCDT latency and graphomotor variables and compares performances between individuals with mild cognitive impairment (MCI) and non-MCI peers. Methods: 202 non-demented older adults (age 68.79 ± 6.18, 46% female, education years 16.02 ± 2.70) completed the dCDT and a comprehensive neuropsychological protocol. dCDT variables of interest included: total completion time (TCT), pre-first hand latency (PFHL), post-clock face latency (PCFL), and clock face area (CFA). We also explored variables of percent time drawing (i.e., 'ink time') versus percent time not drawing (i.e., 'think time'). Neuropsychological domains of interest included processing speed, working memory, language, and declarative memory. Results: Adjusting for age and premorbid cognitive reserve metrics, command TCT positively correlated with multiple cognitive domains; PFHL and PCFL negatively associated with worse performance on working memory and processing speed tests. For Copy, TCT, PCFL, and PFHL negatively correlated with processing speed, and CFA negatively correlated with language. Between-group analyses show MCI participants generated slower command TCT, produced smaller CFA, and required more command 'think' (% Think) than 'ink' (% Ink) time. Conclusion: Command dCDT variables of interest were primarily processing speed and working memory dependent. MCI participants showed dCDT differences relative to non-MCI peers, suggesting the dCDT may assist with classification. Results document cognitive construct validation to digital metrics of clock drawing. |
| first_indexed | 2024-09-23T15:59:51Z |
| format | Article |
| id | mit-1721.1/129815 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:59:51Z |
| publishDate | 2021 |
| publisher | IOS Press |
| record_format | dspace |
| spelling | mit-1721.1/1298152022-10-02T05:38:18Z Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment Dion, Catherine Arias, Franchesca Amini, Shawna Davis, Randall Penney, Dana Libon, David J. Price, Catherine C. Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Background: A digital version of the clock drawing test (dCDT) provides new latency and graphomotor behavioral measurements. These variables have yet to be validated with external neuropsychological domains in non-demented adults. Objective: The current investigation reports on cognitive constructs associated with selected dCDT latency and graphomotor variables and compares performances between individuals with mild cognitive impairment (MCI) and non-MCI peers. Methods: 202 non-demented older adults (age 68.79 ± 6.18, 46% female, education years 16.02 ± 2.70) completed the dCDT and a comprehensive neuropsychological protocol. dCDT variables of interest included: total completion time (TCT), pre-first hand latency (PFHL), post-clock face latency (PCFL), and clock face area (CFA). We also explored variables of percent time drawing (i.e., 'ink time') versus percent time not drawing (i.e., 'think time'). Neuropsychological domains of interest included processing speed, working memory, language, and declarative memory. Results: Adjusting for age and premorbid cognitive reserve metrics, command TCT positively correlated with multiple cognitive domains; PFHL and PCFL negatively associated with worse performance on working memory and processing speed tests. For Copy, TCT, PCFL, and PFHL negatively correlated with processing speed, and CFA negatively correlated with language. Between-group analyses show MCI participants generated slower command TCT, produced smaller CFA, and required more command 'think' (% Think) than 'ink' (% Ink) time. Conclusion: Command dCDT variables of interest were primarily processing speed and working memory dependent. MCI participants showed dCDT differences relative to non-MCI peers, suggesting the dCDT may assist with classification. Results document cognitive construct validation to digital metrics of clock drawing. National Science Foundation (Grant 1404333) 2021-02-18T15:50:42Z 2021-02-18T15:50:42Z 2020-05 2020-12-07T18:13:15Z Article http://purl.org/eprint/type/JournalArticle 1387-2877 1875-8908 https://hdl.handle.net/1721.1/129815 Dion, Catherine et al. "Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment." Journal of Alzheimer's Disease 75, 1 (May 2020): 73-83. © 2020 IOS Press and the authors en http://dx.doi.org/10.3233/jad-191089 Journal of Alzheimer's Disease Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf IOS Press PMC |
| spellingShingle | Dion, Catherine Arias, Franchesca Amini, Shawna Davis, Randall Penney, Dana Libon, David J. Price, Catherine C. Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title | Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title_full | Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title_fullStr | Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title_full_unstemmed | Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title_short | Cognitive Correlates of Digital Clock Drawing Metrics in Older Adults with and without Mild Cognitive Impairment |
| title_sort | cognitive correlates of digital clock drawing metrics in older adults with and without mild cognitive impairment |
| url | https://hdl.handle.net/1721.1/129815 |
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