Ultrasound-triggered local anaesthesia
On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve blocks in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Springer Nature America, Inc
2021
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| Online Access: | https://hdl.handle.net/1721.1/130004 |
| _version_ | 1826204379330379776 |
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| author | Rwei, Alina Y Paris, Juan L. Wang, Bruce Wang, Weiping Axon, Christopher D. Vallet-Regí, María Langer, Robert S Kohane, Daniel S. |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Rwei, Alina Y Paris, Juan L. Wang, Bruce Wang, Weiping Axon, Christopher D. Vallet-Regí, María Langer, Robert S Kohane, Daniel S. |
| author_sort | Rwei, Alina Y |
| collection | MIT |
| description | On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve blocks in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve blocks to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produced reactive oxygen species that reacted with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin. Repeatable ultrasound-triggered nerve blocks were achieved in vivo, with the nerve-block duration depending on the extent and intensity of insonation. There was no detectable systemic toxicity and tissue reaction was benign in all groups. On-demand, personalized local anaesthesia could be beneficial for the management of relatively localized pain states and could potentially minimize opioid use. ©2017 The Author(s). |
| first_indexed | 2024-09-23T12:53:47Z |
| format | Article |
| id | mit-1721.1/130004 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:53:47Z |
| publishDate | 2021 |
| publisher | Springer Nature America, Inc |
| record_format | dspace |
| spelling | mit-1721.1/1300042022-10-01T11:46:42Z Ultrasound-triggered local anaesthesia Rwei, Alina Y Paris, Juan L. Wang, Bruce Wang, Weiping Axon, Christopher D. Vallet-Regí, María Langer, Robert S Kohane, Daniel S. Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve blocks in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve blocks to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produced reactive oxygen species that reacted with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin. Repeatable ultrasound-triggered nerve blocks were achieved in vivo, with the nerve-block duration depending on the extent and intensity of insonation. There was no detectable systemic toxicity and tissue reaction was benign in all groups. On-demand, personalized local anaesthesia could be beneficial for the management of relatively localized pain states and could potentially minimize opioid use. ©2017 The Author(s). NIH grant (GM073626) Ministerio de Economía y Competitividad, Spain, for PhD grant (BES-2013-064182) Ministerio de Economía y Competitividad, Spain, for PhD grant (EEBB-I-16-11313) MAT2012-35556 2021-02-26T02:27:59Z 2021-02-26T02:27:59Z 2017-08 2016-12 2019-09-03T17:02:08Z Article http://purl.org/eprint/type/JournalArticle 2157-846X https://hdl.handle.net/1721.1/130004 Rwei, Alina Y. et al., "Ultrasound-triggered local anaesthesia." Nature Biomedical Engineering 1, 8 (August 2017): 644–53 ©2017 Authors en https://dx.doi.org/10.1038/S41551-017-0117-6 Nature Biomedical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Springer Nature America, Inc PMC |
| spellingShingle | Rwei, Alina Y Paris, Juan L. Wang, Bruce Wang, Weiping Axon, Christopher D. Vallet-Regí, María Langer, Robert S Kohane, Daniel S. Ultrasound-triggered local anaesthesia |
| title | Ultrasound-triggered local anaesthesia |
| title_full | Ultrasound-triggered local anaesthesia |
| title_fullStr | Ultrasound-triggered local anaesthesia |
| title_full_unstemmed | Ultrasound-triggered local anaesthesia |
| title_short | Ultrasound-triggered local anaesthesia |
| title_sort | ultrasound triggered local anaesthesia |
| url | https://hdl.handle.net/1721.1/130004 |
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